Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 3/20 | 0.36 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5611705 | 1.00 | CA1 (0.43) | CA1CA9BBOX1CA4FAHD1 | |
| Fumaric Acid SCHEMBL20610493 | 1.00 | CA1 (0.43) | CA1CA9BBOX1CA4FAHD1 | |
| Fumaric Acid SCHEMBL4964900 | 1.00 | CA1 (0.43) | CA1CA9BBOX1CA4FAHD1 | |
| Fumaric Acid SCHEMBL5073825 | 1.00 | CA1 (0.43) | CA1CA9BBOX1CA4FAHD1 | |
| Fumaric Acid SCHEMBL6553020 | 0.95 | CA1 (0.45) | CA1CA9BBOX1CA4FAHD1 | |
| Fumaric Acid SCHEMBL21815723 | 0.95 | CA1 (0.45) | CA1CA9BBOX1CA4FAHD1 | |
| Fumaric Acid SCHEMBL6553031 | 0.95 | CA1 (0.45) | CA1CA9BBOX1CA4FAHD1 | |
| Fumaric Acid SCHEMBL23828619 | 0.91 | — | — | |
| Fumaric Acid SCHEMBL21815644 | 0.91 | CA1 (0.43) | CA1CA9BBOX1CA4FAHD1 | |
| Fumaric Acid SCHEMBL15646089 | 0.91 | CA1 (0.43) | CA1CA9BBOX1CA4FAHD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200290267-A1 | Three-Dimensional Printing of Impregnated Plastics for Chemical Reactions | UCL BUSINESS PLC (GB) | 2020-09-17 | — | — | US | disclosed |
| EP-3430473-A1 | THREE-DIMENSIONAL PRINTING OF IMPREGNATED PLASTICS FOR CHEMICAL REACTIONS | UCL Business Plc. (GB) | 2019-01-23 | — | — | EP | disclosed |