Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8951802 | 0.83 | ALDH1A1 (0.37) | HRH3 | |
| SCHEMBL2064252 | 0.73 | ALDH1A1 (0.40) | — | |
| SCHEMBL10657113 | 0.73 | ALDH1A1 (0.40) | — | |
| SCHEMBL10657108 | 0.73 | ALDH1A1 (0.40) | — | |
| SCHEMBL8951777 | 0.72 | BCHE (0.51) | BCHEACHE | |
| SCHEMBL2066098 | 0.72 | HRH3 (0.55) | HRH3SIGMAR1 | |
| SCHEMBL9756628 | 0.69 | BCHE (0.41) | BCHEACHEHRH3SIGMAR1 | |
| SCHEMBL11502411 | 0.69 | BCHE (0.56) | BCHEACHEDRD2SIGMAR1 | |
| SCHEMBL16596978 | 0.69 | BCHE (0.53) | BCHEACHEHRH3SIGMAR1 | |
| SCHEMBL2067120 | 0.69 | BCHE (0.53) | BCHEACHEHRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111233763-B | Preparation method of 1- (4-methoxy-benzyl) -2-methyl-octahydroisoquinoline | 苏州敬业医药化工有限公司 | 2022-03-18 | — | — | CN | claimed |
| CN-111233763-A | Preparation method of 1- (4-methoxy-benzyl) -2-methyl-octahydroisoquinoline | 苏州敬业医药化工有限公司 | 2020-06-05 | — | — | CN | claimed |
| CN-111233763-B | Preparation method of 1- (4-methoxy-benzyl) -2-methyl-octahydroisoquinoline | 苏州敬业医药化工有限公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-111233763-B | Preparation method of 1- (4-methoxy-benzyl) -2-methyl-octahydroisoquinoline | 苏州敬业医药化工有限公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-111233763-B | Preparation method of 1- (4-methoxy-benzyl) -2-methyl-octahydroisoquinoline | 苏州敬业医药化工有限公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-111233763-A | Preparation method of 1- (4-methoxy-benzyl) -2-methyl-octahydroisoquinoline | 苏州敬业医药化工有限公司 | 2020-06-05 | — | — | CN | disclosed |
| CN-111233763-A | Preparation method of 1- (4-methoxy-benzyl) -2-methyl-octahydroisoquinoline | 苏州敬业医药化工有限公司 | 2020-06-05 | — | — | CN | disclosed |
| CN-111233763-A | Preparation method of 1- (4-methoxy-benzyl) -2-methyl-octahydroisoquinoline | 苏州敬业医药化工有限公司 | 2020-06-05 | — | — | CN | disclosed |
| EP-2628728-B1 | PROCESS FOR THE OPTICAL RESOLUTION OF 1-(4-METHOXYBENZYL)-OCTAHYDROISOQUINOLINE | DIVI'S LABORATORIES LTD (IN) | 2017-04-19 | — | — | EP | disclosed |
| EP-2628728-A1 | Process for the optical resolution of 1-(4-methoxybenzyl)-octahydro-isoquinoline | Divi's Laboratories Limited (IN) | 2013-08-21 | — | — | EP | disclosed |
| US-8148527-B1 | Resolution of 1-(4-methoxybenzyl)-octahydro-isoquinoline | Divi's Laboratories, Ltd. (IN) | 2012-04-03 | — | — | US | disclosed |
| US-5512577-A | Bicyclic hexahydroaporphine and 1-benzyloctahydroisoquinoline therapeutic compositions and processes for utilizing said compositions | CREIGHTON UNIVERSITY (US) | 1996-04-30 | — | — | US | disclosed |
| US-5332821-A | Process for preparing isoquinolines | HOFFMANN-LA ROCHE INC. (US) | 1994-07-26 | — | — | US | disclosed |
| EP-0283848-B1 | PROCESS FOR THE PREPARATION OF ISOQUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 1991-05-15 | — | — | EP | disclosed |