Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8951806 | 0.82 | OPRK1 (0.43) | OPRK1HRH3 | |
| SCHEMBL11760720 | 0.76 | HRH3 (0.46) | HRH3SIGMAR1 | |
| SCHEMBL11760698 | 0.76 | HRH3 (0.46) | HRH3SIGMAR1 | |
| SCHEMBL11768994 | 0.76 | HRH3 (0.46) | HRH3SIGMAR1 | |
| SCHEMBL11769008 | 0.76 | HRH3 (0.46) | HRH3SIGMAR1 | |
| SCHEMBL11760710 | 0.76 | HRH3 (0.46) | HRH3SIGMAR1 | |
| SCHEMBL11766646 | 0.72 | HRH3 (0.45) | HRH3SIGMAR1 | |
| SCHEMBL11763720 | 0.72 | HRH3 (0.45) | HRH3SIGMAR1 | |
| SCHEMBL11763716 | 0.72 | HRH3 (0.45) | HRH3SIGMAR1 | |
| SCHEMBL11499924 | 0.71 | HRH3 (0.50) | OPRK1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111233763-B | Preparation method of 1- (4-methoxy-benzyl) -2-methyl-octahydroisoquinoline | 苏州敬业医药化工有限公司 | 2022-03-18 | — | — | CN | claimed |
| CN-111233763-A | Preparation method of 1- (4-methoxy-benzyl) -2-methyl-octahydroisoquinoline | 苏州敬业医药化工有限公司 | 2020-06-05 | — | — | CN | claimed |
| CN-111233763-B | Preparation method of 1- (4-methoxy-benzyl) -2-methyl-octahydroisoquinoline | 苏州敬业医药化工有限公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-111233763-B | Preparation method of 1- (4-methoxy-benzyl) -2-methyl-octahydroisoquinoline | 苏州敬业医药化工有限公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-111233763-B | Preparation method of 1- (4-methoxy-benzyl) -2-methyl-octahydroisoquinoline | 苏州敬业医药化工有限公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-111233763-A | Preparation method of 1- (4-methoxy-benzyl) -2-methyl-octahydroisoquinoline | 苏州敬业医药化工有限公司 | 2020-06-05 | — | — | CN | disclosed |
| CN-111233763-A | Preparation method of 1- (4-methoxy-benzyl) -2-methyl-octahydroisoquinoline | 苏州敬业医药化工有限公司 | 2020-06-05 | — | — | CN | disclosed |
| CN-111233763-A | Preparation method of 1- (4-methoxy-benzyl) -2-methyl-octahydroisoquinoline | 苏州敬业医药化工有限公司 | 2020-06-05 | — | — | CN | disclosed |
| EP-2628728-B1 | PROCESS FOR THE OPTICAL RESOLUTION OF 1-(4-METHOXYBENZYL)-OCTAHYDROISOQUINOLINE | DIVI'S LABORATORIES LTD (IN) | 2017-04-19 | — | — | EP | disclosed |
| CN-103319406-A | Resolution of 1-(4-methoxybenzyl)-octahydro-isoquinoline | DIVIS LAB LTD | 2013-09-25 | — | — | CN | disclosed |
| EP-2628728-A1 | Process for the optical resolution of 1-(4-methoxybenzyl)-octahydro-isoquinoline | Divi's Laboratories Limited (IN) | 2013-08-21 | — | — | EP | disclosed |
| US-8148527-B1 | Resolution of 1-(4-methoxybenzyl)-octahydro-isoquinoline | Divi's Laboratories, Ltd. (IN) | 2012-04-03 | — | — | US | disclosed |
| US-5512577-A | Bicyclic hexahydroaporphine and 1-benzyloctahydroisoquinoline therapeutic compositions and processes for utilizing said compositions | CREIGHTON UNIVERSITY (US) | 1996-04-30 | — | — | US | disclosed |