Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 8/20 | 0.66 |
| ▸ | NPC1 | O15118 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.48 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20661210 | 0.89 | NPC1 (0.65) | ROCK2NPC1RAB9AROCK1MEN1 | |
| SCHEMBL20661246 | 0.89 | ROCK2 (0.54) | ROCK2NPC1RAB9AROCK1MEN1 | |
| SCHEMBL20661209 | 0.88 | ROCK2 (0.63) | ROCK2NPC1RAB9AROCK1MEN1 | |
| SCHEMBL20661228 | 0.88 | ROCK2 (0.63) | ROCK2NPC1RAB9AROCK1MAOB | |
| SCHEMBL20661200 | 0.87 | ROCK2 (0.59) | ROCK2NPC1RAB9AROCK1JAK2 | |
| SCHEMBL20661242 | 0.87 | NPC1 (0.63) | ROCK2NPC1RAB9AROCK1MEN1 | |
| SCHEMBL20661252 | 0.86 | NPC1 (0.62) | ROCK2NPC1RAB9AROCK1MEN1 | |
| SCHEMBL20661250 | 0.86 | NPC1 (0.62) | ROCK2NPC1RAB9AROCK1MEN1 | |
| SCHEMBL20661195 | 0.86 | ROCK2 (0.69) | ROCK2NPC1RAB9AROCK1MAOB | |
| SCHEMBL20661237 | 0.84 | NPC1 (0.60) | ROCK2NPC1RAB9AROCK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11926596-B2 | Inhibitors of Rho associated coiled-coil containing protein kinase | KADMON CORPORATION, LLC (US) | 2024-03-12 | — | — | US | claimed |
| US-20240190827-A1 | Inhibitors of Rho Associated Coiled-Coil Containing Protein Kinase | KADMON CORPORATION, LLC (US) | 2024-06-13 | — | — | US | disclosed |
| US-11926596-B2 | Inhibitors of Rho associated coiled-coil containing protein kinase | KADMON CORPORATION, LLC (US) | 2024-03-12 | — | — | US | disclosed |
| US-20210163421-A1 | INHIBITORS OF RHO ASSOCIATED COILED-COIL CONTAINING PROTEIN KINASE | KADMON PHARMACEUTICALS, LLC | 2021-06-03 | — | — | US | disclosed |
| US-20210163421-A1 | INHIBITORS OF RHO ASSOCIATED COILED-COIL CONTAINING PROTEIN KINASE | KADMON PHARMACEUTICALS, LLC | 2021-06-03 | — | — | US | disclosed |
| CN-111278437-A | RHO-related inhibitors of coiled-coil protein kinase | 卡德门企业有限公司 | 2020-06-12 | — | — | CN | disclosed |
| EP-3654972-A1 | INHIBITORS OF RHO ASSOCIATED COILED-COIL CONTAINING PROTEIN KINASE | Kadmon Corporation, LLC (US) | 2020-05-27 | — | — | EP | disclosed |
| WO-2019018853-A1 | INHIBITORS OF RHO ASSOCIATED COILED-COIL CONTAINING PROTEIN KINASE | KADMON CORPORATION, LLC (US) | 2019-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210163421-A1 | INHIBITORS OF RHO ASSOCIATED COILED-COIL CONTAINING PROTEIN KINASE | ROCK1, ROCK2, RHOT2 | ROCK2 2/4885NPC1 2291/4885RAB9A 442/4885 |
| US-11926596-B2 | Inhibitors of Rho associated coiled-coil containing protein kinase | ROCK1, ROCK2, ARHGDIA | ROCK2 2/4885NPC1 1879/4885RAB9A 365/4885 |
| US-20240190827-A1 | Inhibitors of Rho Associated Coiled-Coil Containing Protein Kinase | ROCK1, ROCK2, RHOT2 | ROCK2 2/4885NPC1 2291/4885RAB9A 442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.