Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | GCGR | P47871 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29904837 | 0.82 | ALDH1A1 (0.50) | DHODHCCNE1CDK2KDM4EALDH1A1 | |
| SCHEMBL14760220 | 0.82 | ALDH1A1 (0.50) | DHODHCCNE1CDK2KDM4EALDH1A1 | |
| SCHEMBL1902851 | 0.79 | KDM4E (0.68) | DHODHPOLBKDM4EALDH1A1TDP1 | |
| SCHEMBL16343486 | 0.76 | DHODH (0.47) | DHODHPOLBKDM4EALDH1A1TDP1 | |
| SCHEMBL18529536 | 0.74 | PLK4 (0.55) | POLBCCNB2CCNE2CDK1CCNB1 | |
| SCHEMBL8604469 | 0.74 | POLB (0.58) | DHODHPOLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL26322070 | 0.73 | ALDH1A1 (0.46) | POLBALDH1A1TDP1L3MBTL1TSHR | |
| SCHEMBL25683007 | 0.73 | ALDH1A1 (0.46) | DHODHPOLBALDH1A1TDP1P2RX7 | |
| SCHEMBL14769542 | 0.73 | PLK4 (0.40) | KDM4EALDH1A1RAB9AMAPT | |
| SCHEMBL17730705 | 0.72 | ALDH1A1 (0.61) | POLBKDM4EALDH1A1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2791137-B1 | PYRAZOLOPYRIDINE DERIVATIVES, PREPARATION PROCESS THEREFOR AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2019-01-23 | — | — | EP | disclosed |