Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18927468 | 0.83 | ALDH1A1 (0.51) | ALDH1A1KMT2AMEN1TSHRTDP1 | |
| SCHEMBL2700303 | 0.82 | ALDH1A1 (0.50) | ALDH1A1KMT2ATSHRTDP1SLC6A2 | |
| Hydrochloric Acid SCHEMBL2700297 | 0.81 | ALDH1A1 (0.49) | ALDH1A1KMT2AMEN1TSHRTDP1 | |
| SCHEMBL18529536 | 0.76 | PLK4 (0.55) | ALDH1A1KMT2AMEN1TSHRTDP1 | |
| SCHEMBL24965965 | 0.75 | ALDH1A1 (0.44) | ALDH1A1KMT2AMEN1TDP1SLC6A2 | |
| SCHEMBL24966566 | 0.75 | ALDH1A1 (0.44) | ALDH1A1KMT2AMEN1TDP1SLC6A2 | |
| SCHEMBL50441 | 0.75 | ALDH1A1 (0.89) | ALDH1A1KMT2ATSHRTDP1SLC6A2 | |
| SCHEMBL29388715 | 0.75 | ALDH1A1 (0.89) | ALDH1A1KMT2ATSHRTDP1SLC6A2 | |
| SCHEMBL2701264 | 0.75 | ALDH1A1 (0.55) | ALDH1A1KMT2ATSHRTDP1SLC6A2 | |
| SCHEMBL23812437 | 0.74 | ALDH1A1 (0.69) | ALDH1A1KMT2ATSHRTDP1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200385386-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS AND USES THEREOF | ANGEX PHARMACEUTICAL, INC. | 2020-12-10 | — | — | US | disclosed |
| EP-3215505-B1 | PIPERIDINYLPYRAZOLOPYRIMIDINONES AND THEIR USE | Bayer Pharma AG (DE) | 2019-07-24 | — | — | EP | disclosed |
| US-10118930-B2 | Piperidinylpyrazolopyrimidinones and their use | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-11-06 | — | — | US | disclosed |
| US-20170334917-A1 | PIPERIDINYLPYRAZOLOPYRIMIDINONES AND THEIR USE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-11-23 | — | — | US | disclosed |
| EP-3215505-A1 | PIPERIDINYLPYRAZOLOPYRIMIDINONES AND THEIR USE | Bayer Pharma Aktiengesellschaft (DE) | 2017-09-13 | — | — | EP | disclosed |
| WO-2016071216-A1 | PIPERIDINYLPYRAZOLOPYRIMIDINONES AND THEIR USE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200385386-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS AND USES THEREOF | MAP3K20, PNCK, CDC42BPG | ALDH1A1 4711/4885KMT2A 2625/4885MEN1 2324/4885 |
| US-10118930-B2 | Piperidinylpyrazolopyrimidinones and their use | HAMP, SERPINC1, PRSS8 | ALDH1A1 404/4885KMT2A 3881/4885MEN1 1501/4885 |
| US-20170334917-A1 | PIPERIDINYLPYRAZOLOPYRIMIDINONES AND THEIR USE | HAMP, SERPINC1, PRSS8 | ALDH1A1 404/4885KMT2A 3881/4885MEN1 1501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.