Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23894246 | 0.83 | SCN1A (0.32) | SCN1ASCN2ASCN3ANAMPTKDM4E | |
| SCHEMBL19022026 | 0.81 | KMT2A (0.38) | KMT2ASCN1ASCN2ASCN3ANAMPT | |
| SCHEMBL29889358 | 0.81 | ALDH1A1 (0.39) | ALDH1A1KMT2APOLBKDM4ETP53 | |
| SCHEMBL20670324 | 0.80 | CHRM5 (0.40) | ALDH1A1KMT2ANAMPTKDM4E | |
| SCHEMBL20670356 | 0.79 | ALDH1A1 (0.38) | ALDH1A1KDM1AKMT2APOLBKDM4E | |
| SCHEMBL20670328 | 0.79 | KDM4E (0.43) | ALDH1A1KMT2ANAMPTPOLBKDM4E | |
| SCHEMBL18936836 | 0.78 | ALDH1A1 (0.37) | ALDH1A1KMT2ASLC22A1SLC6A4ADRA1A | |
| SCHEMBL8684584 | 0.78 | ALDH1A1 (0.42) | ALDH1A1KDM1AKMT2A | |
| SCHEMBL15232200 | 0.78 | KMT2A (0.42) | ALDH1A1KDM1AKMT2ASCN1ASCN2A | |
| SCHEMBL29722496 | 0.76 | SCN1A (0.34) | KMT2ASCN1ASCN2ASCN3ANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303514-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2023-09-28 | — | — | US | disclosed |
| EP-4248968-A2 | TLR7/8 ANTAGONISTS AND USES THEREOF | Merck Patent GmbH (DE) | 2023-09-27 | — | — | EP | disclosed |
| EP-3655401-B1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2023-09-06 | — | — | EP | disclosed |
| US-10836750-B1 | TLR7/8 antagonists and uses thereof | MERCK PATENT GMBH (DE) | 2020-11-17 | — | — | US | disclosed |
| US-10793553-B2 | TLR7/8 antagonists and uses thereof | MERCK PATENT GMBH (DE) | 2020-10-06 | — | — | US | disclosed |
| US-20190023687-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230303514-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | TLR7, TLR8, TLR9 | ALDH1A1 2648/4885KDM1A 856/4885KMT2A 1063/4885 |
| US-20190023687-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | TLR7, TLR8, TLR9 | ALDH1A1 2465/4885KDM1A 1004/4885KMT2A 1153/4885 |
| US-10793553-B2 | TLR7/8 antagonists and uses thereof | TLR7, TLR8, TLR9 | ALDH1A1 2465/4885KDM1A 1004/4885KMT2A 1153/4885 |
| US-10836750-B1 | TLR7/8 antagonists and uses thereof | TLR7, TLR8, TLR9 | ALDH1A1 2746/4885KDM1A 1042/4885KMT2A 1096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.