Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8263662 | 0.83 | HDAC6 (0.34) | ALDH1A1SMN1; SMN2LMNAUSP2CYP1A2 | |
| SCHEMBL8689460 | 0.79 | LMNA (0.39) | ALDH1A1SMN1; SMN2LMNAUSP2CYP1A2 | |
| SCHEMBL11571536 | 0.79 | ALDH1A1 (0.34) | ALDH1A1SMN1; SMN2LMNAUSP2CYP1A2 | |
| SCHEMBL29889214 | 0.78 | CYP2C19 (0.43) | ALDH1A1SMN1; SMN2LMNAUSP2CYP1A2 | |
| SCHEMBL20670355 | 0.78 | ALDH1A1 (0.39) | ALDH1A1KDM1AKMT2A | |
| SCHEMBL24512534 | 0.77 | HSD11B1 (0.46) | ALDH1A1SMN1; SMN2LMNAUSP2CYP1A2 | |
| SCHEMBL22271223 | 0.77 | ALDH1A1 (0.32) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL8263659 | 0.76 | HDAC3 (0.36) | — | |
| SCHEMBL178371 | 0.75 | CYP2C19 (0.54) | ALDH1A1SMN1; SMN2LMNAUSP2CYP1A2 | |
| SCHEMBL27932912 | 0.75 | CYP2C19 (0.38) | ALDH1A1SMN1; SMN2LMNAUSP2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780473-A | Substituted biphenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-07-14 | — | — | US | claimed |
| US-5780473-A | Substituted biphenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-07-14 | — | — | US | disclosed |