Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMO | Q99835 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.42 |
| ▸ | TUBB | P07437 | 2/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20116723 | 0.88 | LMNA (0.42) | LMNAALOX15TSHRMAPK1SMO | |
| SCHEMBL20676566 | 0.86 | LMNA (0.47) | LMNAALOX15TSHRMAPK1ALDH1A1 | |
| SCHEMBL20676712 | 0.79 | GRM5 (0.40) | — | |
| SCHEMBL20117192 | 0.79 | TLR9 (0.51) | LMNAALOX15TSHRMAPK1SMO | |
| SCHEMBL390887 | 0.76 | LMNA (0.67) | LMNAALOX15TSHRMAPK1CYP3A4 | |
| SCHEMBL20676705 | 0.76 | SMO (0.49) | LMNATSHRSMOALDH1A1MAPT | |
| SCHEMBL20676430 | 0.75 | LMNA (0.41) | LMNAALOX15TSHRMAPK1SMO | |
| SCHEMBL20116325 | 0.75 | TLR9 (0.49) | LMNAALOX15TSHRMAPK1SMO | |
| SCHEMBL20117208 | 0.74 | MAPT (0.40) | LMNASMOALDH1A1MAPTHTT | |
| SCHEMBL22358012 | 0.74 | LMNA (0.43) | LMNAALOX15TSHRMAPK1SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2019018795-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2019-01-24 | — | — | WO | disclosed |