Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.40 |
| ▸ | LMNA | P02545 | 6/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | SMO | Q99835 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20676648 | 0.89 | MAPT (0.40) | MAPTLMNAHTTNPC1TP53 | |
| SCHEMBL20116723 | 0.87 | LMNA (0.42) | LMNASMO | |
| SCHEMBL20676712 | 0.85 | GRM5 (0.40) | — | |
| SCHEMBL20116879 | 0.83 | MAPT (0.36) | MAPTLMNAHTTNPC1TP53 | |
| SCHEMBL20116844 | 0.78 | MAPT (0.35) | MAPTLMNAHTTNPC1MEN1 | |
| SCHEMBL20116146 | 0.77 | MAPT (0.41) | MAPTLMNAHTTNPC1TP53 | |
| SCHEMBL20117300 | 0.75 | FAAH (0.39) | FAAH | |
| SCHEMBL20117187 | 0.75 | MAPT (0.44) | MAPTLMNAHTTNPC1TP53 | |
| SCHEMBL20676430 | 0.75 | LMNA (0.41) | LMNAHTTSMN1; SMN2SMO | |
| SCHEMBL20676567 | 0.74 | LMNA (0.44) | MAPTLMNAHTTSMN1; SMN2SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |