Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.49 |
| ▸ | USP2 | O75604 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | HTR1A | P08908 | 3/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.49 |
| ▸ | HRH1 | P35367 | 3/20 | 0.49 |
| ▸ | DRD3 | P35462 | 3/20 | 0.49 |
| ▸ | HTR6 | P50406 | 3/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19127667 | 0.82 | SIGMAR1 (0.70) | SIGMAR1CYP3A4CYP2D6USP2LMNA | |
| SCHEMBL19153976 | 0.79 | SIGMAR1 (0.65) | SIGMAR1CYP3A4CYP2D6USP2LMNA | |
| SCHEMBL7603081 | 0.78 | SIGMAR1 (0.64) | SIGMAR1CYP3A4CYP2D6USP2LMNA | |
| Acetic Acid SCHEMBL8172274 | 0.78 | SIGMAR1 (0.64) | SIGMAR1CYP3A4CYP2D6USP2LMNA | |
| SCHEMBL7605940 | 0.76 | SIGMAR1 (0.60) | SIGMAR1CYP3A4CYP2D6USP2LMNA | |
| SCHEMBL8181729 | 0.76 | SIGMAR1 (0.60) | SIGMAR1CYP3A4CYP2D6USP2LMNA | |
| SCHEMBL19126835 | 0.74 | CYP3A4 (0.80) | SIGMAR1CYP3A4CYP2D6USP2LMNA | |
| SCHEMBL8176002 | 0.74 | CHRM1 (0.47) | SIGMAR1ADRA1AHRH1HTR2ACHRM1 | |
| SCHEMBL7604550 | 0.74 | SLC6A1 (0.58) | SIGMAR1CYP2D6LMNACYP1A2CYP2C19 | |
| SCHEMBL8172276 | 0.73 | SIGMAR1 (0.60) | SIGMAR1CYP3A4CYP2D6USP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10766873-B2 | Zuclopenthixol hydrochloride derivatives and Ebselen derivatives as ErbB2 inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2020-09-08 | — | — | US | disclosed |
| US-20190031639-A1 | ZUCLOPENTHIXOL HYDROCHLORIDE DERIVATIVES AND EBSELEN DERIVATIVES AS ERBB2 INHIBITORS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2019-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190031639-A1 | ZUCLOPENTHIXOL HYDROCHLORIDE DERIVATIVES AND EBSELEN DERIVATIVES AS ERBB2 INHIBITORS | ERBB2, ERBB3, EGFR | SIGMAR1 3662/4885CYP3A4 3407/4885CYP2D6 2315/4885 |
| US-10766873-B2 | Zuclopenthixol hydrochloride derivatives and Ebselen derivatives as ErbB2 inhibitors | ERBB2, ERBB3, EGFR | SIGMAR1 3662/4885CYP3A4 3407/4885CYP2D6 2315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.