Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GPR183 | P32249 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16772292 | 0.88 | SMN1; SMN2 (0.45) | HDAC6ERBB2HDAC8HDAC1RAB9A | |
| SCHEMBL1128943 | 0.82 | HDAC8 (0.50) | HDAC6ERBB2HDAC8ALDH1A1KDM4C | |
| SCHEMBL9917430 | 0.81 | HDAC6 (0.57) | HDAC6ERBB2HDAC8CYP1A2CYP2D6 | |
| SCHEMBL662061 | 0.79 | IDO1 (0.45) | HDAC6ERBB2ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL1637329 | 0.78 | HDAC8 (0.39) | HDAC6HDAC8ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL31394603 | 0.75 | HDAC8 (0.38) | HDAC8ALDH1A1RAB9ASMN1; SMN2PDE5A | |
| SCHEMBL6101289 | 0.74 | HDAC8 (0.40) | HDAC6HDAC8ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL20680657 | 0.73 | CYP11B1 (0.33) | HDAC6CYP11B1CYP11B2ALDH1A1TDP1 | |
| SCHEMBL13042 | 0.73 | NPC1 (0.50) | ERBB2ALDH1A1TDP1KDM4CRAB9A | |
| SCHEMBL146444 | 0.72 | HDAC8 (0.38) | HDAC6HDAC8ALDH1A1RAB9ABACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019021208-A1 | INDAZOLE DERIVATIVES USEFUL AS PERK INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-01-31 | — | — | WO | disclosed |
| WO-2019021208-A1 | INDAZOLE DERIVATIVES USEFUL AS PERK INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-01-31 | — | — | WO | disclosed |