Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20680665 | 0.86 | RIPK1 (0.32) | HDAC1L3MBTL1HDAC6 | |
| SCHEMBL20719264 | 0.78 | NPC1 (0.36) | KMT2ARAB9ASMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL20680673 | 0.73 | HDAC6 (0.42) | CYP11B1CYP11B2HDAC1RAB9ADUSP3 | |
| SCHEMBL25592850 | 0.73 | KMT2A (0.43) | KMT2AHDAC1RAB9ADUSP3SMN1; SMN2 | |
| SCHEMBL20680666 | 0.71 | EIF2AK3 (0.44) | — | |
| SCHEMBL21631668 | 0.70 | MET (0.35) | ALDH1A1 | |
| SCHEMBL31424377 | 0.69 | — | — | |
| SCHEMBL24879334 | 0.66 | ADORA3 (0.42) | RAB9ASMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL25592835 | 0.66 | MEN1 (0.45) | KMT2ARAB9ASMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL3222034 | 0.66 | L3MBTL1 (0.49) | CYP11B1CYP11B2KMT2ARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019021208-A1 | INDAZOLE DERIVATIVES USEFUL AS PERK INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-01-31 | — | — | WO | disclosed |