Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 9/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.52 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.45 |
| ▸ | SCD | O00767 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18629758 | 0.84 | TRPV1 (0.63) | CHEK2TRPV1NPBWR1HDAC6HPSE | |
| SCHEMBL26358087 | 0.80 | HDAC6 (0.60) | TRPV1NPBWR1HDAC6SCD | |
| SCHEMBL20681741 | 0.78 | CHEK2 (0.46) | CHEK2TRPV1NPBWR1HDAC6HPSE | |
| SCHEMBL9058427 | 0.77 | HDAC6 (0.62) | TRPV1NPBWR1HDAC6SCD | |
| SCHEMBL12250680 | 0.77 | HDAC6 (0.61) | TRPV1NPBWR1HDAC6SCD | |
| SCHEMBL22326618 | 0.77 | SCN10A (0.55) | CHEK2TRPV1NPBWR1HDAC6SCD | |
| SCHEMBL12961102 | 0.76 | SCN10A (0.46) | TRPV1HDAC6 | |
| SCHEMBL19190854 | 0.76 | CHEK2 (0.64) | CHEK2TRPV1HPSE | |
| SCHEMBL10330717 | 0.75 | CHEK2 (0.51) | CHEK2NPBWR1HPSE | |
| SCHEMBL4182601 | 0.73 | CHEK2 (0.67) | CHEK2TRPV1NPBWR1HDAC6HPSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10188992-B2 | Polybenzimidazoles and methods of making and using thereof | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10188992-B2 | Polybenzimidazoles and methods of making and using thereof | PHB2, SI, NISCH | CHEK2 1763/4885TRPV1 380/4885NPBWR1 3374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.