Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL894670 | 0.86 | ARG1 (0.46) | SMN1; SMN2CHRM2ALDH1A1KDM4ETHRB | |
| Hydrochloric Acid SCHEMBL894540 | 0.85 | ARG1 (0.46) | SMN1; SMN2CHRM2ALDH1A1KDM4ETHRB | |
| SCHEMBL14896852 | 0.83 | TSHR (0.40) | SMN1; SMN2S1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL20156733 | 0.77 | S1PR1 (0.46) | SMN1; SMN2S1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL894960 | 0.74 | ARG1 (0.45) | SMN1; SMN2S1PR2S1PR1S1PR3 | |
| Hydrochloric Acid SCHEMBL896060 | 0.73 | ARG1 (0.44) | SMN1; SMN2S1PR2S1PR1S1PR3 | |
| SCHEMBL14879650 | 0.70 | ARG1 (0.45) | SMN1; SMN2S1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL27922741 | 0.69 | CHRM2 (0.62) | SMN1; SMN2CHRM2ALDH1A1KDM4ETHRB | |
| SCHEMBL27880074 | 0.69 | CHRM2 (0.50) | SMN1; SMN2CHRM2ALDH1A1KDM4ETHRB | |
| SCHEMBL5303258 | 0.68 | CHRM2 (0.61) | SMN1; SMN2CHRM2ALDH1A1KDM4ETHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560978-B1 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS | MARS INC (US) | 2019-01-30 | — | — | EP | disclosed |