Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 8/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 8/20 | 0.46 |
| ▸ | S1PR2 | O95136 | 7/20 | 0.46 |
| ▸ | LPAR2 | Q9HBW0 | 5/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | HTR5A | P47898 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL894960 | 0.88 | ARG1 (0.45) | S1PR1S1PR3S1PR2LPAR2ALOX15 | |
| Hydrochloric Acid SCHEMBL896060 | 0.87 | ARG1 (0.44) | S1PR1S1PR3S1PR2LPAR2ALOX15 | |
| SCHEMBL14896852 | 0.85 | TSHR (0.40) | S1PR1S1PR3S1PR2ALOX15S1PR4 | |
| SCHEMBL14879650 | 0.84 | ARG1 (0.45) | S1PR1S1PR3S1PR2ALOX15S1PR4 | |
| SCHEMBL28256955 | 0.81 | ALOX15 (0.47) | S1PR1S1PR3S1PR2LPAR2ALOX15 | |
| SCHEMBL9775999 | 0.78 | TSHR (0.38) | S1PR1S1PR3S1PR2S1PR4SMN1; SMN2 | |
| SCHEMBL14058901 | 0.77 | SMN1; SMN2 (0.59) | S1PR1S1PR3S1PR2LPAR2ALOX15 | |
| SCHEMBL20683376 | 0.77 | SMN1; SMN2 (0.45) | S1PR1S1PR3S1PR2S1PR4SMN1; SMN2 | |
| SCHEMBL894670 | 0.75 | ARG1 (0.46) | S1PR1S1PR3S1PR2S1PR4SMN1; SMN2 | |
| SCHEMBL19055966 | 0.73 | SMN1; SMN2 (0.41) | S1PR1S1PR3S1PR2LPAR2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089490-A1 | ARGINASE INHIBITOR COMBINATION THERAPIES | CALITHERA BIOSCIENCES, INC. (US) | 2018-05-17 | — | — | WO | disclosed |