Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14879650 | 0.87 | ARG1 (0.45) | TSHRALOX15CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL20156733 | 0.85 | S1PR1 (0.46) | TSHRALOX15CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL20683376 | 0.83 | SMN1; SMN2 (0.45) | SMN1; SMN2S1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL894960 | 0.83 | ARG1 (0.45) | TSHRALOX15CYP1A2CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL896060 | 0.82 | ARG1 (0.44) | TSHRALOX15CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL28256955 | 0.71 | ALOX15 (0.47) | TSHRALOX15CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL894670 | 0.70 | ARG1 (0.46) | SMN1; SMN2S1PR2S1PR4S1PR1S1PR3 | |
| Hydrochloric Acid SCHEMBL894540 | 0.69 | ARG1 (0.46) | SMN1; SMN2S1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL5939885 | 0.68 | FFAR1 (0.60) | TSHRALOX15CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL9775999 | 0.68 | TSHR (0.38) | TSHRSMN1; SMN2TRPV1FFAR1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768491-B1 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS | MARS INC (US) | 2016-12-21 | — | — | EP | disclosed |
| WO-2013059437-A1 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS | MARS, INCORPORATED (US) | 2013-04-25 | — | — | WO | disclosed |