Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.51 |
| ▸ | RAB9A | P51151 | 7/20 | 0.51 |
| ▸ | PPARG | P37231 | 6/20 | 0.49 |
| ▸ | PPARD | Q03181 | 6/20 | 0.49 |
| ▸ | PPARA | Q07869 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ARG1 | P05089 | 2/20 | 0.47 |
| ▸ | ARG2 | P78540 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL895033 | 0.90 | ARG1 (0.60) | NPC1RAB9APPARGPPARDPPARA | |
| Hydrochloric Acid SCHEMBL16291141 | 0.89 | ARG1 (0.59) | NPC1RAB9APPARGPPARDPPARA | |
| SCHEMBL20683384 | 0.80 | ARG1 (0.46) | ARG1ARG2 | |
| SCHEMBL20683534 | 0.76 | ARG1 (0.50) | PPARGPPARDPPARAMAPTARG1 | |
| SCHEMBL15919892 | 0.74 | NPC1 (0.62) | NPC1RAB9APPARGPPARDPPARA | |
| SCHEMBL20683386 | 0.73 | ARG1 (0.48) | SMN1; SMN2MAPTARG1ARG2 | |
| SCHEMBL1729140 | 0.73 | PPARG (0.60) | NPC1RAB9APPARGPPARDPPARA | |
| SCHEMBL334720 | 0.73 | NPC1 (0.70) | NPC1RAB9APPARGPPARDPPARA | |
| SCHEMBL333717 | 0.73 | NPC1 (0.70) | NPC1RAB9APPARGPPARDPPARA | |
| SCHEMBL334455 | 0.73 | NPC1 (0.62) | NPC1RAB9APPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560978-B1 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS | MARS INC (US) | 2019-01-30 | — | — | EP | disclosed |