Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 11/20 | 0.50 |
| ▸ | ARG2 | P78540 | 11/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL895072 | 0.89 | ARG1 (0.66) | ARG1ARG2KDM4EMAPTDEGS1 | |
| SCHEMBL30170023 | 0.89 | ARG1 (0.66) | ARG1ARG2KDM4EMAPTDEGS1 | |
| Hydrochloric Acid SCHEMBL895238 | 0.88 | ARG1 (0.64) | ARG1ARG2KDM4EMAPTDEGS1 | |
| SCHEMBL20683409 | 0.85 | LMNA (0.56) | ARG1ARG2KDM4EMAPT | |
| SCHEMBL20683386 | 0.82 | ARG1 (0.48) | ARG1ARG2KDM4EMAPT | |
| SCHEMBL20683397 | 0.77 | ARG1 (0.58) | ARG1ARG2MAPT | |
| SCHEMBL20683420 | 0.76 | FFAR4 (0.50) | ARG1ARG2KDM4EMAPTPPARG | |
| SCHEMBL20683392 | 0.76 | NPC1 (0.51) | ARG1ARG2MAPTPPARGPPARD | |
| SCHEMBL20683402 | 0.76 | ARG1 (0.60) | ARG1ARG2 | |
| SCHEMBL20683503 | 0.75 | ARG1 (0.79) | ARG1ARG2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560978-B1 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS | MARS INC (US) | 2019-01-30 | — | — | EP | disclosed |