Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | HTR5A | P47898 | 4/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL894260 | 0.90 | ARG1 (0.46) | HDAC6ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL30169841 | 0.90 | ARG1 (0.46) | HDAC6ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL894261 | 0.90 | ARG1 (0.46) | HDAC6ADORA2AADORA1ADORA3ADORA2B | |
| Hydrochloric Acid SCHEMBL895194 | 0.89 | ARG1 (0.46) | HDAC6ADORA2AADORA1ADORA3ADORA2B | |
| Hydrochloric Acid SCHEMBL2566685 | 0.89 | ARG1 (0.46) | HDAC6ADORA2AADORA1ADORA3ADORA2B | |
| Hydrochloric Acid SCHEMBL895195 | 0.89 | ARG1 (0.46) | HDAC6ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL20683408 | 0.81 | ARG1 (0.50) | HTR5A | |
| Hydrochloric Acid SCHEMBL28256811 | 0.78 | HTR5A (0.38) | HDAC6ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL14897262 | 0.77 | SLC6A2 (0.36) | GRM2GRM3 | |
| SCHEMBL20683526 | 0.75 | GRM2 (0.48) | GRM2GRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560978-B1 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS | MARS INC (US) | 2019-01-30 | — | — | EP | disclosed |