Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 11/20 | 0.50 |
| ▸ | ARG2 | P78540 | 11/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR1F | P30939 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL894216 | 0.90 | ARG1 (0.65) | ARG1ARG2KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL895235 | 0.89 | ARG1 (0.64) | ARG1ARG2KMT2AALDH1A1 | |
| SCHEMBL20683513 | 0.81 | HDAC6 (0.40) | HTR5A | |
| SCHEMBL20683414 | 0.81 | ARG1 (0.50) | ARG1ARG2ALDH1A1HTR1AHTR1D | |
| SCHEMBL20683430 | 0.79 | ARG1 (0.51) | ARG1ARG2ALDH1A1 | |
| SCHEMBL20683511 | 0.79 | ARG1 (0.57) | ARG1ARG2ALDH1A1HTR7 | |
| SCHEMBL28258408 | 0.79 | ALDH1A1 (0.44) | KMT2AALDH1A1MEN1CYP3A4CYP2D6 | |
| SCHEMBL20683483 | 0.78 | ARG1 (0.56) | ARG1ARG2KMT2AALDH1A1MEN1 | |
| SCHEMBL10265155 | 0.78 | ARG1 (0.77) | ARG1ARG2KMT2AMEN1 | |
| SCHEMBL16309661 | 0.78 | ARG1 (0.77) | ARG1ARG2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560978-B1 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS | MARS INC (US) | 2019-01-30 | — | — | EP | disclosed |