Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 0.48 |
| ▸ | RORA | P35398 | 1/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17858293 | 0.83 | RORC (0.47) | RORCRORABCL2L1MCL1SLC6A2 | |
| SCHEMBL17858292 | 0.81 | RORC (0.48) | RORCRORABCL2L1MCL1SLC6A2 | |
| SCHEMBL20684519 | 0.80 | MAPT (0.53) | RORCESR1POLBKMT2ACA12 | |
| SCHEMBL17843936 | 0.74 | VCAM1 (0.54) | RORCRORAHTT | |
| SCHEMBL20684504 | 0.73 | RORC (0.48) | RORCRORAESR1POLBCA12 | |
| SCHEMBL3653313 | 0.71 | ALDH1A1 (0.53) | CA12CA1CA2CA9HTT | |
| SCHEMBL17858322 | 0.70 | RORC (0.51) | RORCRORACNR2 | |
| SCHEMBL17852206 | 0.70 | RORC (0.53) | RORCRORACNR2 | |
| SCHEMBL8533738 | 0.70 | CA12 (0.53) | CA12CA1CA2CA9 | |
| SCHEMBL17852354 | 0.70 | RORC (0.50) | RORCPOLBMEN1KMT2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233836-B1 | INDAZOLE SULFONAMIDE DERIVATIVES AS INVERSE AGONISTS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR GAMMA (T)) | GALDERMA RES & DEV (FR) | 2019-01-30 | — | — | EP | disclosed |