Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.32 |
| ▸ | MARK3 | P27448 | 5/20 | 0.31 |
| ▸ | MARK4 | Q96L34 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20686168 | 0.85 | TP53 (0.30) | — | |
| SCHEMBL17275845 | 0.81 | PROKR1 (0.37) | PROKR1MARK3MARK4 | |
| SCHEMBL20686163 | 0.77 | MAP4K1 (0.34) | PROKR1 | |
| SCHEMBL15577412 | 0.76 | ABL1 (0.47) | — | |
| SCHEMBL20686277 | 0.75 | — | — | |
| SCHEMBL17275720 | 0.74 | F2 (0.36) | MARK3MARK4 | |
| SCHEMBL16322116 | 0.73 | GAA (0.39) | — | |
| SCHEMBL20686190 | 0.73 | TP53 (0.31) | — | |
| SCHEMBL20686268 | 0.72 | ALDH1A1 (0.36) | — | |
| SCHEMBL15578852 | 0.72 | ABL1 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145923-B1 | INDOLIN-2-ONE AND 1,3-DIHYDRO-PYRROLO[3,2-C]PYRIDIN-2-ONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2019-01-30 | — | — | EP | disclosed |