Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.30 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.30 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20686168 | 0.87 | TP53 (0.30) | — | |
| SCHEMBL20686158 | 0.85 | ALDH1A1 (0.35) | ALDH1A1KMT2AKDM4EMAPTHTT | |
| SCHEMBL20686145 | 0.80 | ALDH1A1 (0.38) | ALDH1A1KMT2AKDM4EMAPTHTT | |
| SCHEMBL17275758 | 0.76 | ALDH1A1 (0.47) | ALDH1A1KMT2AKDM4EMAPTHTT | |
| SCHEMBL17275671 | 0.76 | ALDH1A1 (0.49) | ALDH1A1KMT2AKDM4EMAPTHTT | |
| SCHEMBL20686169 | 0.76 | LMNA (0.43) | KMT2AKDM4EMAPTHTTLMNA | |
| SCHEMBL20686277 | 0.75 | — | — | |
| SCHEMBL20686190 | 0.74 | TP53 (0.31) | — | |
| SCHEMBL16322756 | 0.73 | PRSS1 (0.39) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9142318 | 0.73 | LMNA (0.46) | LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145923-B1 | INDOLIN-2-ONE AND 1,3-DIHYDRO-PYRROLO[3,2-C]PYRIDIN-2-ONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2019-01-30 | — | — | EP | disclosed |