Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | CFTR | P13569 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | ATM | Q13315 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 5/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18950889 | 0.86 | HSD17B10 (0.55) | HSD17B10ALDH1A1CFTRKDM4EATM | |
| SCHEMBL940016 | 0.86 | KDM4E (0.68) | HSD17B10ALDH1A1CFTRKDM4EATM | |
| SCHEMBL29919844 | 0.85 | KDM4E (0.71) | HSD17B10ALDH1A1CFTRKDM4EATM | |
| SCHEMBL2136524 | 0.85 | KDM4E (0.71) | HSD17B10ALDH1A1CFTRKDM4EATM | |
| SCHEMBL2895994 | 0.85 | ALDH1A1 (0.67) | HSD17B10ALDH1A1CFTRKDM4EATM | |
| Hydrochloric Acid SCHEMBL28488399 | 0.83 | KDM4E (0.69) | HSD17B10ALDH1A1CFTRKDM4EATM | |
| Hydrochloric Acid SCHEMBL28498072 | 0.81 | FFAR4 (0.55) | HSD17B10ALDH1A1CFTRKDM4EATM | |
| SCHEMBL25932317 | 0.81 | PDK1 (0.56) | HSD17B10ALDH1A1CFTRKDM4EATM | |
| SCHEMBL12068032 | 0.80 | ALDH1A1 (0.49) | HSD17B10ALDH1A1CFTRKDM4EATM | |
| SCHEMBL31589985 | 0.79 | ALDH1A1 (0.71) | HSD17B10ALDH1A1CFTRKDM4EATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3658565-B1 | CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2022-11-09 | — | — | EP | disclosed |
| WO-2019046498-A1 | CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-03-07 | — | — | WO | disclosed |
| WO-2019023459-A1 | CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-01-31 | — | — | WO | disclosed |