Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.41 |
| ▸ | MEN1 | O00255 | 9/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | POLB | P06746 | 4/20 | 0.38 |
| ▸ | RECQL | P46063 | 4/20 | 0.38 |
| ▸ | THRB | P10828 | 3/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31634616 | 0.84 | KMT2A (0.54) | KMT2AMEN1TDP1KDM4EHSD17B10 | |
| Sulfachrysoidine SCHEMBL49739 | 0.80 | PTGS2 (0.60) | KMT2AMEN1TDP1HSD17B10CYP1A2 | |
| Sulfachrysoidine SCHEMBL49738 | 0.80 | PTGS2 (0.60) | KMT2AMEN1TDP1HSD17B10CYP1A2 | |
| SCHEMBL17471609 | 0.76 | MEN1 (0.44) | KMT2AMEN1TDP1KDM4EHSD17B10 | |
| SCHEMBL11925227 | 0.73 | PTPN11 (0.50) | KMT2AMEN1TDP1KDM4EHSD17B10 | |
| SCHEMBL31634579 | 0.72 | CCNE2 (0.55) | KMT2AMEN1TDP1KDM4ECYP2C19 | |
| SCHEMBL14183998 | 0.70 | TDP1 (0.60) | KMT2AMEN1TDP1KDM4EHSD17B10 | |
| SCHEMBL13619065 | 0.69 | KMT2A (0.46) | KMT2AMEN1TDP1KDM4EHSD17B10 | |
| SCHEMBL13065575 | 0.68 | HSD17B10 (0.49) | KMT2AMEN1TDP1KDM4EHSD17B10 | |
| SCHEMBL12906940 | 0.67 | MAPT (0.44) | KMT2AMEN1TDP1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10428058-B2 | Prodrugs of NH-acidic compounds | ALKERMES PHARMA IRELAND LIMITED (IE) | 2019-10-01 | — | — | US | disclosed |
| US-20190284181-A9 | PRODRUGS OF NH-ACIDIC COMPOUNDS | JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT | 2019-09-19 | — | — | US | disclosed |
| US-20190031648-A1 | PRODRUGS OF NH-ACIDIC COMPOUNDS | ALKERMES PHARMA IRELAND LTD (IE) | 2019-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190031648-A1 | PRODRUGS OF NH-ACIDIC COMPOUNDS | SI, NAAA, NIT2 | KMT2A 1192/4885MEN1 1428/4885TDP1 3433/4885 |
| US-20190284181-A9 | PRODRUGS OF NH-ACIDIC COMPOUNDS | SI, NAAA, NIT2 | KMT2A 1192/4885MEN1 1428/4885TDP1 3433/4885 |
| US-10428058-B2 | Prodrugs of NH-acidic compounds | SI, NAAA, NIT2 | KMT2A 1192/4885MEN1 1428/4885TDP1 3433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.