SCHEMBL20699536

SCHEMBL20699536

C#Cc1cc2ccccc2c(O)c1C#C

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.39
PTPN22 Q9Y2R2 2/20 0.39
KDM4E B2RXH2 2/20 0.39
MEN1 O00255 2/20 0.39
MAPT P10636 2/20 0.39
KMT2A Q03164 2/20 0.39
TRPM4 Q8TD43 1/20 0.39
GAA P10253 1/20 0.39
CACNA1B Q00975 1/20 0.39
APBA1 Q02410 1/20 0.39
CASP6 P55212 1/20 0.39
NQO2 P16083 1/20 0.38
NQO1 P15559 1/20 0.38
HIF1A Q16665 1/20 0.34
CYP1B1 Q16678 1/20 0.34
HSD17B10 Q99714 1/20 0.34
LDHA P00338 1/20 0.34
HPGD P15428 1/20 0.34
MPI P34949 1/20 0.34
CYP1A2 P05177 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7940388 0.75 PTPN22 (0.54) ALDH1A1PTPN22HIF1AHSD17B10LDHA
SCHEMBL10338293 0.74 KDM4E (0.59) ALDH1A1PTPN22KDM4EMEN1MAPT
SCHEMBL31587957 0.74 TRPM4 (0.46) ALDH1A1MAPTTRPM4HIF1ACYP1B1
SCHEMBL313567 0.74 TRPM4 (0.46) ALDH1A1MAPTTRPM4HIF1ACYP1B1
SCHEMBL738593 0.73 ALDH1A1 (0.44) ALDH1A1KDM4EMEN1KMT2ATRPM4
SCHEMBL29344478 0.73 NQO2 (0.55) ALDH1A1KDM4EMEN1MAPTKMT2A
SCHEMBL29937378 0.73 NQO2 (0.55) ALDH1A1KDM4EMEN1MAPTKMT2A
SCHEMBL26135366 0.73 TRPM4 (0.38) ALDH1A1PTPN22KDM4EMEN1MAPT
Benzene SCHEMBL28903867 0.71 ALDH1A1 (0.45) ALDH1A1PTPN22KDM4EMEN1MAPT
SCHEMBL20699497 0.70 ALDH1A1 (0.39) ALDH1A1PTPN22KDM4EMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11360387-B2 Silicon-containing underlayers ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2022-06-14 US disclosed
US-20190041751-A1 SILICON-CONTAINING UNDERLAYERS U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS NOTES COLLATERAL AGENT 2019-02-07 US disclosed