Sugi Predict

Sugi Predict / Compounds / SCHEMBL20705103

SCHEMBL20705103

SCHEMBL20705103

O=C(O)c1cn2cc(C(F)(F)F)ccc2n1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PTGS1 P23219 1/20 0.53
▸ PTGS2 P35354 1/20 0.53
▸ KDM4E B2RXH2 2/20 0.52
▸ NPC1 O15118 2/20 0.52
▸ ALDH1A1 P00352 2/20 0.52
▸ HPGD P15428 2/20 0.52
▸ SMN1; SMN2 Q16637 2/20 0.52
▸ POLB P06746 1/20 0.52
▸ NFKB1 P19838 1/20 0.52
▸ RAB9A P51151 1/20 0.52
▸ GFER P55789 1/20 0.52
▸ NFKB2 Q00653 1/20 0.52
▸ RELA Q04206 1/20 0.52
▸ RCE1 Q9Y256 1/20 0.52
▸ MAPT P10636 1/20 0.47
▸ METTL3 Q86U44 1/20 0.46
▸ MCHR1 Q99705 9/20 0.43
▸ USP7 Q93009 1/20 0.40
▸ EGLN1 Q9GZT9 2/20 0.39
▸ MAP3K5 Q99683 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13791874 0.86 KDM4E (0.51) PTGS1PTGS2KDM4ENPC1ALDH1A1
SCHEMBL30828885 0.86 KDM4E (0.51) KDM4ENPC1ALDH1A1HPGDSMN1; SMN2
SCHEMBL30845761 0.85 MCHR1 (0.48) KDM4ENPC1ALDH1A1HPGDSMN1; SMN2
Hydrochloric Acid SCHEMBL3885254 0.84 KDM4E (0.50) PTGS1PTGS2KDM4ENPC1ALDH1A1
SCHEMBL15829285 0.84 PTGS1 (0.53) PTGS1PTGS2MCHR1EGLN1MAP3K5
SCHEMBL21033531 0.84 KDM4E (0.52) PTGS1PTGS2KDM4ENPC1ALDH1A1
SCHEMBL2086971 0.84 NPC1 (0.47) PTGS1PTGS2KDM4ENPC1ALDH1A1
Bromide SCHEMBL2086999 0.83 METTL3 (0.46) PTGS1PTGS2KDM4ENPC1ALDH1A1
Hydrochloric Acid SCHEMBL2087444 0.83 METTL3 (0.46) PTGS1PTGS2KDM4ENPC1ALDH1A1
SCHEMBL3883777 0.80 KDM4E (0.60) KDM4ENPC1ALDH1A1HPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4076459-B1 PRMT5 INHIBITORS MERCK SHARP & DOHME LLC (US) 2026-04-29 — — EP disclosed
US-20260101898-A1 SULFONAMIDE COMPOUND AND HARMFUL-ARTHROPOD CONTROLLING COMPOSITION CONTAINING SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2026-04-16 — — US disclosed
US-12595248-B2 PRMT5 inhibitors MERCK SHARP & DOHME LLC (US) 2026-04-07 — — US disclosed
EP-4603491-A1 SULFONAMIDE COMPOUND AND HARMFUL-ARTHROPOD CONTROLLING COMPOSITION CONTAINING SAME Sumitomo Chemical Company, Limited (JP) 2025-08-20 — — EP disclosed
EP-4494698-A2 INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF Takeda Pharmaceutical Company Limited (JP) 2025-01-22 — — EP disclosed
EP-3661922-B1 INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2024-10-23 — — EP disclosed
US-20240199602-A1 INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2024-06-20 — — US disclosed
WO-2024080330-A1 SULFONAMIDE COMPOUND AND HARMFUL-ARTHROPOD CONTROLLING COMPOSITION CONTAINING SAME 住友化学株式会社 2024-04-18 — — WO disclosed
EP-3704120-B1 HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS JUBILANT EPISCRIBE LLC (US) 2024-03-06 — — EP disclosed
US-11905285-B2 Inhibitors of plasma kallikrein and uses thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2024-02-20 — — US disclosed
US-20210371431-A1 HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS JUBILANT EPISCRIBE LLC 2021-12-02 — — US disclosed
US-11168083-B2 Inhibitors of Plasma Kallikrein and uses thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2021-11-09 — — US disclosed
WO-2021126728-A1 PRMT5 INHIBITORS MERCK SHARP & DOHME CORP. (US) 2021-06-24 — — WO disclosed
WO-2021126728-A1 PRMT5 INHIBITORS MERCK SHARP & DOHME CORP. (US) 2021-06-24 — — WO disclosed
EP-3704120-A1 HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS Jubilant Episcribe LLC (US) 2020-09-09 — — EP disclosed
US-20200239463-A1 INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF DYAX CORP. (US) 2020-07-30 — — US disclosed
EP-3661922-A1 INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF Dyax Corp. (US) 2020-06-10 — — EP disclosed
WO-2019102494-A1 HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS JUBILANT BIOSYS LIMITED (IN) 2019-05-31 — — WO disclosed
WO-2019102494-A1 HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS JUBILANT BIOSYS LIMITED (IN) 2019-05-31 — — WO disclosed
WO-2019028362-A1 INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF DYAX CORP. (US) 2019-02-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240199602-A1 INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF KLKB1, KLK1, KLK5 PTGS1 151/4885PTGS2 441/4885KDM4E 1766/4885
US-12595248-B2 PRMT5 inhibitors PRMT5, PRMT1, PRMT6 PTGS1 3174/4885PTGS2 3718/4885KDM4E 306/4885
US-11168083-B2 Inhibitors of Plasma Kallikrein and uses thereof KLKB1, KLK1, KLK5 PTGS1 151/4885PTGS2 441/4885KDM4E 1766/4885
US-20200239463-A1 INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF KLKB1, KLK1, KLK5 PTGS1 151/4885PTGS2 441/4885KDM4E 1766/4885
US-20210371431-A1 HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS PRMT5, PRMT1, PRMT3 PTGS1 2236/4885PTGS2 3251/4885KDM4E 221/4885
US-11905285-B2 Inhibitors of plasma kallikrein and uses thereof KLKB1, KLK1, KLK5 PTGS1 151/4885PTGS2 441/4885KDM4E 1766/4885
US-20260101898-A1 SULFONAMIDE COMPOUND AND HARMFUL-ARTHROPOD CONTROLLING COMPOSITION CONTAINING SAME COX6B1, CYC1, COX6C PTGS1 184/4885PTGS2 372/4885KDM4E 2896/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.