SCHEMBL20705307

SCHEMBL20705307

O=C1NN=C(c2ccc(-c3ccccc3C(F)F)c(F)c2)CO1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PDE3B Q13370 20/20 1.00
PDE3A Q14432 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30692565 1.00 PDE3B (1.00) PDE3BPDE3A
SCHEMBL20702890 0.89 PDE3B (1.00) PDE3BPDE3A
SCHEMBL20703184 0.85 PDE3B (1.00) PDE3BPDE3A
SCHEMBL30580684 0.85 PDE3B (1.00) PDE3BPDE3A
SCHEMBL30580676 0.85 PDE3B (1.00) PDE3BPDE3A
SCHEMBL20703242 0.85 PDE3B (1.00) PDE3BPDE3A
SCHEMBL20702635 0.85 PDE3B (1.00) PDE3BPDE3A
SCHEMBL20702748 0.84 PDE3B (1.00) PDE3BPDE3A
SCHEMBL20702640 0.83 PDE3B (1.00) PDE3BPDE3A
SCHEMBL20703306 0.83 PDE3B (1.00) PDE3BPDE3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111212647-B Dihydro oxadiazinones 拜耳股份有限公司 2024-05-14 CN claimed
CN-117279644-A Substituted 3, 6-dihydro-2H-1, 3, 4-oxadiazin-2-ones for the treatment of sarcomas 拜耳股份有限公司 2023-12-22 CN claimed
US-20230405015-A1 SUBSTITUTED 3,6-DIHYDRO-2H-1,3,4-OXADIAZIN-2-ONES FOR THE TREATMENT OF SARCOMA BAYER AKTIENGESELLSCHAFT (DE) 2023-12-21 US claimed
EP-3661517-B1 DIHYDROOXADIAZINONES BAYER AG (DE) 2023-09-13 EP claimed
US-20230017200-A1 DIHYDROOXADIAZINONES BAYER AKTIENGESELLSCHAFT (DE) 2023-01-19 US claimed
US-20200369633-A1 DIHYDROOXADIAZINONES BAYER AKTIENGESELLSCHAFT (DE) 2020-11-26 US claimed
EP-3661517-A1 DIHYDROOXADIAZINONES Bayer Aktiengesellschaft (DE) 2020-06-10 EP claimed
CN-111212647-A Dihydroxadiazinones 拜耳股份有限公司 2020-05-29 CN claimed
WO-2019025562-A1 DIHYDROOXADIAZINONES BAYER AKTIENGESELLSCHAFT (DE) 2019-02-07 WO claimed
US-12258323-B2 Dihydrooxadiazinones BAYER AKTIENGESELLSCHAFT (DE) 2025-03-25 US disclosed
CN-111212647-B Dihydro oxadiazinones 拜耳股份有限公司 2024-05-14 CN disclosed
CN-117279644-A Substituted 3, 6-dihydro-2H-1, 3, 4-oxadiazin-2-ones for the treatment of sarcomas 拜耳股份有限公司 2023-12-22 CN disclosed
US-20230405015-A1 SUBSTITUTED 3,6-DIHYDRO-2H-1,3,4-OXADIAZIN-2-ONES FOR THE TREATMENT OF SARCOMA BAYER AKTIENGESELLSCHAFT (DE) 2023-12-21 US disclosed
US-11773070-B2 Dihydrooxadiazinones BAYER AKTIENGESELLSCHAFT (DE) 2023-10-03 US disclosed
US-20200369633-A1 DIHYDROOXADIAZINONES BAYER AKTIENGESELLSCHAFT (DE) 2020-11-26 US disclosed
US-20200369633-A1 DIHYDROOXADIAZINONES BAYER AKTIENGESELLSCHAFT (DE) 2020-11-26 US disclosed
EP-3661517-A1 DIHYDROOXADIAZINONES Bayer Aktiengesellschaft (DE) 2020-06-10 EP disclosed
CN-111212647-A Dihydroxadiazinones 拜耳股份有限公司 2020-05-29 CN disclosed
WO-2019025562-A1 DIHYDROOXADIAZINONES BAYER AKTIENGESELLSCHAFT (DE) 2019-02-07 WO disclosed
WO-2019025562-A1 DIHYDROOXADIAZINONES BAYER AKTIENGESELLSCHAFT (DE) 2019-02-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200369633-A1 DIHYDROOXADIAZINONES CCND2, CCNT2, CCND1 PDE3B 1101/4885PDE3A 1148/4885
US-11773070-B2 Dihydrooxadiazinones CCND2, DPYD, DHPS PDE3B 1205/4885PDE3A 1283/4885
US-12258323-B2 Dihydrooxadiazinones CCND2, CCNT2, CCND1 PDE3B 1101/4885PDE3A 1148/4885
US-20230405015-A1 SUBSTITUTED 3,6-DIHYDRO-2H-1,3,4-OXADIAZIN-2-ONES FOR THE TREATMENT OF SARCOMA EWSR1, SDHA, IDH3B PDE3B 1781/4885PDE3A 1719/4885
US-20230017200-A1 DIHYDROOXADIAZINONES CCND2, CCNT2, CCND1 PDE3B 1101/4885PDE3A 1148/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.