Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.33 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18328884 | 0.80 | TDP2 (0.37) | NPC1RAB9APARP1PARP10ESR1 | |
| SCHEMBL18328888 | 0.78 | ESR1 (0.40) | PARP1PARP10ESR1ESR2CYP11B1 | |
| SCHEMBL6939165 | 0.77 | CYP11B1 (0.33) | IP6K1IP6K3ESR1ESR2CYP11B1 | |
| SCHEMBL18328889 | 0.75 | TDP2 (0.38) | PARP1PARP10ESR1ESR2CYP11B1 | |
| SCHEMBL2627018 | 0.73 | ALDH1A1 (0.32) | TSHRCYP11B1CYP11B2CYP19A1 | |
| SCHEMBL12259134 | 0.73 | ALDH1A1 (0.44) | NPC1RAB9ACYP11B1CYP11B2CYP19A1 | |
| SCHEMBL6056983 | 0.71 | METAP1 (0.67) | METAP1MAOAMAOBPARP1PARP10 | |
| SCHEMBL1609651 | 0.70 | METAP1 (0.71) | METAP1MAOAMAOBPARP1PARP10 | |
| SCHEMBL6287169 | 0.70 | CYP11B1 (0.54) | MAOANPC1TP53PKMRAB9A | |
| SCHEMBL30487694 | 0.70 | CYP11B1 (0.54) | MAOANPC1TP53PKMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10195213-B2 | Chemical entities that kill senescent cells for use in treating age-related disease | UNITY BIOTECHNOLOGY, INC. (US) | 2019-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10195213-B2 | Chemical entities that kill senescent cells for use in treating age-related disease | TP53, CDKN1A, GLA | METAP1 2980/4885MAOA 1995/4885NPC1 958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.