Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 4/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28084454 | 0.85 | KDR (0.48) | KMT2AMEN1TSHRGAAPKM | |
| SCHEMBL2088365 | 0.80 | EPHX2 (0.48) | KMT2AMEN1GAAKDREPHX2 | |
| SCHEMBL17681593 | 0.80 | ALDH1A1 (0.56) | KMT2AMEN1GAAKDRMAPT | |
| SCHEMBL16820011 | 0.78 | HDAC3 (0.51) | GAAHDAC3HDAC1HDAC2 | |
| SCHEMBL16819996 | 0.78 | HDAC3 (0.51) | GAAHDAC3HDAC1HDAC2 | |
| SCHEMBL7605672 | 0.78 | SMN1; SMN2 (0.68) | KMT2AMEN1TSHRGAAPKM | |
| SCHEMBL28758475 | 0.77 | EPHX2 (0.46) | KMT2AMEN1GAAPKMKDR | |
| SCHEMBL30061549 | 0.76 | PKM (0.53) | GAAPKMMAPT | |
| SCHEMBL27167037 | 0.76 | PKM (0.53) | GAAPKMMAPT | |
| SCHEMBL24251873 | 0.74 | KMT2A (0.71) | KMT2AMEN1GAATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2888229-B1 | alpha7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEREOF | MERCK SHARP & DOHME (US) | 2019-02-06 | — | — | EP | disclosed |