Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | NAAA | Q02083 | 2/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3485153 | 1.00 | CTSB (0.44) | CTSBTSHRTDP1L3MBTL1MMP3 | |
| SCHEMBL3484734 | 1.00 | CTSB (0.44) | CTSBTSHRTDP1L3MBTL1MMP3 | |
| SCHEMBL27604046 | 0.90 | TSHR (0.47) | CTSBTSHRMEN1KMT2ATAAR1 | |
| SCHEMBL28145970 | 0.82 | TDP1 (0.43) | TSHRTDP1L3MBTL1MMP3MMP1 | |
| SCHEMBL18616451 | 0.81 | TSHR (0.52) | CTSBTSHRTDP1L3MBTL1MMP3 | |
| SCHEMBL18940894 | 0.81 | TSHR (0.44) | CTSBTSHRTDP1L3MBTL1MMP3 | |
| SCHEMBL20692515 | 0.80 | TDP1 (0.40) | CTSBTSHRTDP1L3MBTL1MMP3 | |
| SCHEMBL7627184 | 0.80 | TSHR (0.50) | CTSBTSHRMEN1KMT2ATAAR1 | |
| SCHEMBL121000 | 0.80 | TSHR (0.50) | CTSBTSHRMEN1KMT2ATAAR1 | |
| SCHEMBL5228321 | 0.80 | TSHR (0.50) | CTSBTSHRMEN1KMT2ATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7893268-B2 | Epithiolone analogues | UNIVERSITY OF TOLEDO (US) | 2011-02-22 | — | — | US | disclosed |
| US-20110009459-A1 | EPOTHILONE DERIVATIVES | NOVARTIS AG (CH) | 2011-01-13 | — | — | US | disclosed |
| US-7825141-B2 | Epothilone derivatives | NOVARTIS AG (CH) | 2010-11-02 | — | — | US | disclosed |
| US-20090258904-A1 | Epithiolone Analogues | UNIVERSITY OF TOLEDO | 2009-10-15 | — | — | US | disclosed |
| US-20080114040-A1 | Epothilone Derivatives | NOVARTIS AG (CH) | 2008-05-15 | — | — | US | disclosed |
| WO-2007015929-A2 | EPOTHILONE ANALOGUES | UNIVERSITY OF TOLEDO (US) | 2007-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080114040-A1 | Epothilone Derivatives | EPOR, CYP11B2, VKORC1L1 | CTSB 3560/4885TSHR 1420/4885TDP1 4653/4885 |
| US-20090258904-A1 | Epithiolone Analogues | ESRRB, ESR2, ESRRA | CTSB 4411/4885TSHR 2808/4885TDP1 4297/4885 |
| US-20110009459-A1 | EPOTHILONE DERIVATIVES | EPOR, CYP11B2, VKORC1L1 | CTSB 3560/4885TSHR 1420/4885TDP1 4653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.