Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 11/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20705133 | 0.88 | NR1H4 (0.36) | NR1H4SSTR4GRM4POLBALDH1A1 | |
| SCHEMBL20705274 | 0.82 | NR1H4 (0.37) | NR1H4 | |
| SCHEMBL20713785 | 0.79 | NR1H4 (0.39) | NR1H4SSTR4GRM2 | |
| SCHEMBL7214930 | 0.79 | PDPK1 (0.35) | SSTR4POLBALDH1A1 | |
| SCHEMBL22264109 | 0.73 | FBP1 (0.38) | NR1H4ALDH1A1 | |
| SCHEMBL20705108 | 0.73 | FBP1 (0.38) | NR1H4ALDH1A1 | |
| SCHEMBL24493279 | 0.72 | NCEH1 (0.42) | NR1H4SSTR4POLB | |
| SCHEMBL29650188 | 0.72 | NCEH1 (0.42) | NR1H4SSTR4POLB | |
| SCHEMBL27760076 | 0.71 | PLAU (0.41) | NR1H4SSTR4GRM4POLB | |
| SCHEMBL1438293 | 0.71 | PDPK1 (0.36) | NR1H4SSTR4GRM4GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019028362-A1 | INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | DYAX CORP. (US) | 2019-02-07 | — | — | WO | disclosed |