Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.31 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.31 |
| ▸ | WHR1 | P49842 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20714947 | 0.94 | SMN1; SMN2 (0.36) | CHEK2SMN1; SMN2LMNANPY5RPLA2G2A | |
| SCHEMBL20030036 | 0.93 | ATM (0.37) | SMN1; SMN2LMNANPY5RPLA2G2APLA2G4A | |
| SCHEMBL24388302 | 0.91 | L3MBTL1 (0.37) | SMN1; SMN2LMNANPY5RPLA2G2APLA2G4A | |
| SCHEMBL20029876 | 0.91 | ATM (0.38) | SMN1; SMN2LMNANPY5RPLA2G2APLA2G4A | |
| SCHEMBL20029928 | 0.91 | ATM (0.38) | SMN1; SMN2LMNANPY5RPLA2G2APLA2G4A | |
| SCHEMBL24388314 | 0.90 | L3MBTL1 (0.36) | SMN1; SMN2LMNANPY5RPLA2G2APLA2G4A | |
| SCHEMBL20029870 | 0.90 | SMN1; SMN2 (0.36) | CHEK2SMN1; SMN2LMNAPLA2G2APLA2G4A | |
| SCHEMBL20024196 | 0.89 | TBK1 (0.34) | SMN1; SMN2LMNANPY5RPLA2G2APLA2G4A | |
| SCHEMBL20024779 | 0.89 | SMN1; SMN2 (0.33) | SMN1; SMN2LMNANPY5RPLA2G2APLA2G4A | |
| SCHEMBL25147296 | 0.89 | SMN1; SMN2 (0.37) | CHEK2SMN1; SMN2LMNANPY5RALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190044071-A1 | CARBAZOLES WITH TWO DIBENZOFURAN OR DIBENZOTHIOPHENE SUBSTITUENTS | MERCK PATENT GMBH (DE) | 2019-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190044071-A1 | CARBAZOLES WITH TWO DIBENZOFURAN OR DIBENZOTHIOPHENE SUBSTITUENTS | BRD3, BRPF3, DDT | CHEK2 1190/4885SMN1; SMN2 4384/4885LMNA 4865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.