Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 2/20 | 0.39 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9673792 | 0.87 | SMN1; SMN2 (0.76) | SMN1; SMN2CYP1A2CYP2C19CYP2C9KDM4E | |
| SCHEMBL13243006 | 0.85 | SMN1; SMN2 (0.74) | SMN1; SMN2CYP1A2CYP2C19CYP2C9KDM4E | |
| SCHEMBL9673128 | 0.85 | SMN1; SMN2 (0.74) | SMN1; SMN2CYP1A2CYP2C19CYP2C9KDM4E | |
| SCHEMBL9672301 | 0.85 | SMN1; SMN2 (0.74) | SMN1; SMN2CYP1A2CYP2C19CYP2C9KDM4E | |
| SCHEMBL876603 | 0.85 | SMN1; SMN2 (0.73) | SMN1; SMN2CYP1A2CYP2C19CYP2C9KDM4E | |
| SCHEMBL13243011 | 0.84 | SMN1; SMN2 (0.72) | SMN1; SMN2CYP1A2CYP2C19CYP2C9KDM4E | |
| SCHEMBL3637019 | 0.83 | CYP1A2 (1.00) | SMN1; SMN2CYP1A2CYP2C19CYP2C9KDM4E | |
| SCHEMBL9674425 | 0.82 | SMN1; SMN2 (0.69) | SMN1; SMN2CYP1A2CYP2C19CYP2C9KDM4E | |
| SCHEMBL9674423 | 0.82 | SMN1; SMN2 (0.69) | SMN1; SMN2CYP1A2CYP2C19CYP2C9KDM4E | |
| SCHEMBL13243038 | 0.81 | SMN1; SMN2 (0.67) | SMN1; SMN2CYP1A2CYP2C19CYP2C9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230357226-A1 | PREPARATION METHOD AND USE OF PYRAZOLE COMPOUND CONTAINING 1-(3,4-DIMETHOXYPHENYL)-BETA-CARBOLINE UNIT | NANTONG UNIVERSITY (CN) | 2023-11-09 | — | — | US | disclosed |
| US-20230357226-A1 | PREPARATION METHOD AND USE OF PYRAZOLE COMPOUND CONTAINING 1-(3,4-DIMETHOXYPHENYL)-BETA-CARBOLINE UNIT | NANTONG UNIVERSITY (CN) | 2023-11-09 | — | — | US | disclosed |
| US-9242933-B2 | Heterocyclic compounds as positive modulators of metabotropic glutamate receptor 2 (mGlu2 receptor) | AbbVie Deutschland GmbH & Co. KG (DE) | 2016-01-26 | — | — | US | disclosed |
| CN-101687790-B | Heterocyclic compounds as positive modulators of metabotropic glutamate receptor 2(MGLU2 receptor) | ABBVIE INC | 2015-02-11 | — | — | CN | disclosed |
| US-7906537-B2 | Substituted p-diaminobenzene derivatives | H. LUNDBECK A/S (DK) | 2011-03-15 | — | — | US | disclosed |
| EP-2167464-A1 | HETEROCYCLIC COMPOUNDS AS POSITIVE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 (MGLU2 RECEPTOR) | Abbott GmbH & Co. KG (DE) | 2010-03-31 | — | — | EP | disclosed |
| CN-101687790-A | Heterocyclic compounds as positive modulators of metabotropic glutamate receptor 2(MGLU2 receptor) | ABBOTT GMBH & CO KG | 2010-03-31 | — | — | CN | disclosed |
| WO-2008145616-A1 | HETEROCYCLIC COMPOUNDS AS POSITIVE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 (MGLU2 RECEPTOR) | ABBOTT GMBH & CO. KG (DE) | 2008-12-04 | — | — | WO | disclosed |
| US-20080300260-A1 | HETEROCYCLIC COMPOUNDS AS POSITIVE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 (MGLU2 receptor) | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2008-12-04 | — | — | US | disclosed |
| US-20060264496-A1 | Substituted indoline and indole derivatives | H. LUNDBECK A/S (DK) | 2006-11-23 | — | — | US | disclosed |
| WO-2004082677-A1 | SUBSTITUTED P-DIAMINOBENZENE DERIVATIVES | H. LUNDBECK A/S (DK) | 2004-09-30 | — | — | WO | disclosed |
| EP-0644879-A1 | HERBICIDAL PYRAZOLE-(THIO)-CARBOXAMIDES | RHONE POULENC AGRICULTURE LTD. (GB) | 1995-03-29 | — | — | EP | disclosed |
| WO-1993025535-A1 | HERBICIDAL PYRAZOLE-(THIO)-CARBOXAMIDES | RHONE POULENC AGRICULTURE LTD. (GB) | 1993-12-23 | — | — | WO | disclosed |
| EP-0361827-B1 | PYRAZOLE COMPOUNDS, METHOD FOR PRODUCTION THEREOF, USE THEREOF AND INTERMEDIATES FOR PRODUCTION THEREOF | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 1992-12-16 | — | — | EP | disclosed |
| EP-0234045-B1 | A PYRAZOLE OXIME DERIVATIVE AND ITS PRODUCTION AND USE | NIHON NOHYAKU CO., LTD. (JP) | 1992-09-02 | — | — | EP | disclosed |
| US-5028714-A | Chemical intermediate for fungicide, miticide, insecticide | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1991-07-02 | — | — | US | disclosed |
| US-4980345-A | INSECTICIDES, ACARICIDES, FUNGICIDES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1990-12-25 | — | — | US | disclosed |
| EP-0361827-A1 | Pyrazole compounds, method for production thereof, use thereof and intermediates for production thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1990-04-04 | — | — | EP | disclosed |
| US-4843068-A | INSECTICIDES, MITICIDES, FUNGICIDES | NIHON NOHYAKU CO., LTD. (JP) | 1989-06-27 | — | — | US | disclosed |
| EP-0234045-A2 | A pyrazole oxime derivative and its production and use | NIHON NOHYAKU CO., LTD. (JP) | 1987-09-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230357226-A1 | PREPARATION METHOD AND USE OF PYRAZOLE COMPOUND CONTAINING 1-(3,4-DIMETHOXYPHENYL)-BETA-CARBOLINE UNIT | DDC, AADAC, CDK7 | SMN1; SMN2 3362/4885CYP1A2 599/4885CYP2C19 425/4885 |
| US-20060264496-A1 | Substituted indoline and indole derivatives | IDO1, IDO2, INMT | SMN1; SMN2 3318/4885CYP1A2 23/4885CYP2C19 34/4885 |
| US-20080300260-A1 | HETEROCYCLIC COMPOUNDS AS POSITIVE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 (MGLU2 receptor) | GRM2, GRIN2C, GRM1 | SMN1; SMN2 1228/4885CYP1A2 1751/4885CYP2C19 2357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.