SCHEMBL20717652

SCHEMBL20717652

Cc1c(Cl)cc(Oc2cc(Cl)c(O)c(Cl)c2)cc1Cl

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 4/20 0.44
TSHR P16473 3/20 0.44
TTR P02766 2/20 0.44
CYP3A4 P08684 2/20 0.44
ALDH1A1 P00352 1/20 0.44
RECQL P46063 1/20 0.44
HSP90AA1 P07900 1/20 0.44
THRB P10828 1/20 0.41
CYP2C9 P11712 2/20 0.39
CYP2C19 P33261 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
HIF1A Q16665 2/20 0.39
CYP1A2 P05177 1/20 0.39
ALOX15 P16050 1/20 0.39
ALOX12 P18054 1/20 0.39
TP53 P04637 1/20 0.36
HPGD P15428 2/20 0.36
MAPK1 P28482 1/20 0.36
AKR1B1 P15121 1/20 0.35
MAPT P10636 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL272067 0.88 HSD17B10 (0.55) HSD17B10TSHRTTRCYP3A4ALDH1A1
SCHEMBL6234849 0.82 HSP90AA1 (0.44) HSD17B10TSHRTTRCYP3A4ALDH1A1
SCHEMBL10528411 0.81 HSP90AA1 (0.57) HSD17B10TSHRTTRCYP3A4ALDH1A1
SCHEMBL9658450 0.76 HSP90AA1 (0.52) HSD17B10TSHRTTRCYP3A4ALDH1A1
SCHEMBL9644240 0.76 LTA4H (0.52) HSD17B10TSHRTTRCYP3A4ALDH1A1
SCHEMBL11352238 0.74 HSP90AA1 (0.55) HSD17B10TSHRTTRCYP3A4ALDH1A1
SCHEMBL29025470 0.73 CYP3A4 (0.50) HSD17B10TSHRTTRCYP3A4ALDH1A1
SCHEMBL10491609 0.71 HSD17B10 (0.61) HSD17B10TSHRTTRCYP3A4ALDH1A1
SCHEMBL13038931 0.71 HSD17B10 (0.45) HSD17B10TSHRTTRCYP3A4ALDH1A1
SCHEMBL18179763 0.71 HSP90AA1 (0.56) HSD17B10TSHRTTRCYP3A4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11078325-B2 Method of preparing polyurethanes from oligomeric polyol compositions and polyisocyanates PRESIDIUM USA, INC (US) 2021-08-03 US disclosed
US-11072679-B2 Polyurethanes prepared from oligomeric polyol compositions and polyisocyanates PRESIDIUM USA, INC (US) 2021-07-27 US disclosed
US-11072680-B2 Composition comprising oligomeric polyol compositions and polyisocyanates PRESIDIUM USA, INC. (US) 2021-07-27 US disclosed
US-11066512-B2 Method of preparing oligomeric polyol compositions PRESIDIUM USA, INC. (US) 2021-07-20 US disclosed
US-11066511-B2 Oligomeric polyol compositions PRESIDIUM USA, INC. (US) 2021-07-20 US disclosed
US-20190241699-A1 Method of Preparing Polyurethanes From Oligomeric Polyol Compositions and Polyisocyanates PRESIDIUM INNOVATIONS, LLC 2019-08-08 US disclosed
US-20190055345-A1 Polyurethanes Prepared from Oligomeric Polyol Compositions and Polyisocyanates PRESIDIUM INNOVATIONS, LLC 2019-02-21 US disclosed
US-20190055346-A1 Method of Preparing Oligomeric Polyol Compositions PRESIDIUM INNOVATIONS, LLC 2019-02-21 US disclosed
US-20190040184-A1 OLIGOMERIC POLYOL COMPOSITIONS PRESIDIUM INNOVATIONS, LLC 2019-02-07 US disclosed