SCHEMBL20718458

SCHEMBL20718458

C(=C/c1nc2ccccc2s1)\c1ccc(-c2ccccc2)o1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 10/20 0.51
▸ MEN1 O00255 9/20 0.51
▸ KMT2A Q03164 9/20 0.51
▸ RAB9A P51151 8/20 0.51
▸ TDP1 Q9NUW8 2/20 0.51
▸ SMN1; SMN2 Q16637 5/20 0.50
▸ KDM4E B2RXH2 4/20 0.50
▸ ALDH1A1 P00352 3/20 0.50
▸ PKM P14618 2/20 0.50
▸ APP P05067 1/20 0.46
▸ INSR P06213 1/20 0.46
▸ NCOA1 Q15788 1/20 0.46
▸ SNCA P37840 1/20 0.45
▸ NPC1 O15118 6/20 0.43
▸ NPSR1 Q6W5P4 2/20 0.43
▸ CYP1A2 P05177 1/20 0.43
▸ CYP3A4 P08684 1/20 0.43
▸ CYP2D6 P10635 1/20 0.43
▸ CYP2C19 P33261 1/20 0.43
▸ HPGD P15428 4/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20718457 0.91 MEN1 (0.48) MAPTMEN1KMT2ARAB9ATDP1
SCHEMBL20718456 0.90 KMT2A (0.47) MAPTMEN1KMT2ARAB9ATDP1
SCHEMBL20718459 0.86 RAB9A (0.52) MAPTMEN1KMT2ARAB9ATDP1
SCHEMBL20718461 0.78 MAPT (0.46) MAPTMEN1KMT2ARAB9ATDP1
SCHEMBL537849 0.74 MAPT (0.69) MAPTMEN1KMT2ARAB9ATDP1
SCHEMBL31063726 0.74 MAPT (0.69) MAPTMEN1KMT2ARAB9ATDP1
SCHEMBL537848 0.74 MAPT (0.69) MAPTMEN1KMT2ARAB9ATDP1
SCHEMBL319386 0.72 MEN1 (0.77) MAPTMEN1KMT2ARAB9ATDP1
SCHEMBL10619184 0.72 SNCA (0.65) MAPTMEN1KMT2ARAB9ATDP1
SCHEMBL319385 0.72 MEN1 (0.77) MAPTMEN1KMT2ARAB9ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200369659-A1 SELECTIVE LIGANDS FOR TAU AGGREGATES CBD SOLUTIONS AB (SE) 2020-11-26 — — US disclosed
WO-2019025595-A1 SELECTIVE LIGANDS FOR TAU AGGREGATES KARIN & STEN MORTSTEDT CBD SOLUTIONS AB (SE) 2019-02-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200369659-A1 SELECTIVE LIGANDS FOR TAU AGGREGATES MAPT, PSEN1, PSEN2 MAPT 1/4885MEN1 2376/4885KMT2A 4774/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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