SCHEMBL537848

SCHEMBL537848

C(=C/c1nc2ccccc2s1)\c1ccccc1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.69
MEN1 O00255 5/20 0.69
KMT2A Q03164 5/20 0.69
RAB9A P51151 5/20 0.69
SMN1; SMN2 Q16637 3/20 0.69
APP P05067 1/20 0.69
INSR P06213 1/20 0.69
NCOA1 Q15788 1/20 0.69
NPC1 O15118 3/20 0.64
CYP1A2 P05177 1/20 0.64
CYP3A4 P08684 1/20 0.64
CYP2D6 P10635 1/20 0.64
CYP2C19 P33261 1/20 0.64
NPSR1 Q6W5P4 1/20 0.64
TDP1 Q9NUW8 1/20 0.59
KDM4E B2RXH2 2/20 0.58
GAA P10253 2/20 0.58
ALDH1A1 P00352 1/20 0.58
POLB P06746 1/20 0.58
HTT P42858 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31063726 1.00 MAPT (0.69) MAPTMEN1KMT2ARAB9ASMN1; SMN2
SCHEMBL537849 1.00 MAPT (0.69) MAPTMEN1KMT2ARAB9ASMN1; SMN2
SCHEMBL319385 0.94 MEN1 (0.77) MAPTMEN1KMT2ARAB9ASMN1; SMN2
SCHEMBL319386 0.94 MEN1 (0.77) MAPTMEN1KMT2ARAB9ASMN1; SMN2
SCHEMBL29559249 0.94 MEN1 (0.77) MAPTMEN1KMT2ARAB9ASMN1; SMN2
Dimethylamine SCHEMBL11573253 0.93 MAPT (0.67) MAPTMEN1KMT2ARAB9ASMN1; SMN2
SCHEMBL11776645 0.89 MAPT (0.57) MAPTMEN1KMT2ARAB9ASMN1; SMN2
SCHEMBL23111674 0.86 MAPT (0.67) MAPTMEN1KMT2ARAB9ASMN1; SMN2
SCHEMBL2628251 0.86 MEN1 (0.67) MAPTMEN1KMT2ARAB9ASMN1; SMN2
SCHEMBL6606615 0.86 MEN1 (0.67) MAPTMEN1KMT2ARAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8815000-B1 Solid inks comprising liquid crystalline materials XEROX CORPORATION (US) 2014-08-26 US claimed
US-20140225956-A1 SOLID INKS COMPRISING LIQUID CRYSTALLINE MATERIALS XEROX CORPORATION (US) 2014-08-14 US claimed
EP-2414355-A2 FLUORESCENT CELLULAR MARKERS Zayas, Beatriz (US) 2012-02-08 EP claimed
WO-2010135751-A2 FLUORESCENT CELLULAR MARKERS BEATRIZ ZAYAS BEATRIZ (US) 2010-11-25 WO claimed
US-20100256378-A1 FLUORESCENT CELLULAR MARKERS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2010-10-07 US claimed
US-4063894-A CHROMOGEN, HYDROPEROXIDE, THIAZOLE SHIONOGI & CO., LTD. (JA) 1977-12-20 US claimed
JP-1161245-A None JP disclosed
WO-2024240186-A1 SULFUR-CONTAINING FUSED RING COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND PREPARATION METHOD THEREFOR AND USE THEREOF 深圳博芮健制药有限公司 2024-11-28 WO disclosed
WO-2024200263-A1 2-STYRYLBENZOTHIAZOLE DERIVATIVES AS α-SYNUCLEIN BINDING COMPOUNDS EBERHARD KARLS UNIVERSITAET TUEBINGEN MEDIZINISCHE FAKULTAET (DE) 2024-10-03 WO disclosed
EP-4438597-A1 2-STYRYLBENZOTHIAZOLE DERIVATIVES AS A-SYNUCLEIN BINDING COMPOUNDS Eberhard Karls Universität Tübingen Medizinische Fakultät (DE) 2024-10-02 EP disclosed
WO-2024146597-A1 PREPARATION METHOD FOR BENZOTHIAZOLE COMPOUND, AND INTERMEDIATE THEREOF 上海博芮健制药有限公司 2024-07-11 WO disclosed
CN-117924166-A Direct alkenylation of methylazaheteroaryl compounds and benzyl alcohols 常州大学 2024-04-26 CN disclosed
US-11844846-B2 Styrylbenzothiazole derivatives and uses in imaging methods EMORY UNIVERSITY (US) 2023-12-19 US disclosed
US-4880894-A Quaternary ammonium salts used as phase transfer catalyst ALTER, S.A. (ES) 1989-11-14 US disclosed
JP-H01161245-A ELECTROPHOTOGRAPHIC SENSITIVE BODY CANON INC 1989-06-23 JP disclosed
EP-0313221-A2 Photostencils for screenprinting AUTOTYPE INTERNATIONAL LIMITED (GB) 1989-04-26 EP disclosed
EP-0267136-A2 Quaternary ammonium salts used as phase transfer catalysts ALTER, S.A. (ES) 1988-05-11 EP disclosed
US-4063894-A CHROMOGEN, HYDROPEROXIDE, THIAZOLE SHIONOGI & CO., LTD. (JA) 1977-12-20 US disclosed
US-3994724-A SUBSTITUTED ANILINE PHOTOCONDUCTOR SCOTT PAPER COMPANY (US) 1976-11-30 US disclosed
US-3912697-A Light-sensitive polymers EASTMAN KODAK CO 1975-10-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100256378-A1 FLUORESCENT CELLULAR MARKERS AIFM1, CASP3, BAX MAPT 3510/4885MEN1 2951/4885KMT2A 1656/4885
US-11844846-B2 Styrylbenzothiazole derivatives and uses in imaging methods SNCA, NLN, SMN1; SMN2 MAPT 38/4885MEN1 4073/4885KMT2A 3301/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.