Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | ACHE | P22303 | 2/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 6/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 6/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | TLR4 | O00206 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21685672 | 1.00 | CA1 (0.49) | CA1CA2ACHECTSLCTSB | |
| SCHEMBL20722476 | 0.90 | ACHE (0.47) | CA1CA2ACHECTSLCTSB | |
| SCHEMBL21685740 | 0.90 | ACHE (0.47) | CA1CA2ACHECTSLCTSB | |
| SCHEMBL20722926 | 0.84 | CA1 (0.47) | CA1CA2ACHECTSLCTSB | |
| SCHEMBL20722953 | 0.83 | DPP4 (0.43) | CA1CA2ACHECTSLCTSB | |
| SCHEMBL21685859 | 0.83 | DPP4 (0.43) | CA1CA2ACHECTSLCTSB | |
| SCHEMBL21685858 | 0.83 | DPP4 (0.43) | CA1CA2ACHECTSLCTSB | |
| SCHEMBL20722595 | 0.83 | CA1 (0.51) | CA1CA2ACHECTSLCTSB | |
| SCHEMBL21704067 | 0.80 | CA1 (0.45) | CA1CA2ACHECTSLCTSB | |
| SCHEMBL20722797 | 0.78 | CA1 (0.48) | CA1CA2ACHECTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3665169-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | Forma Therapeutics, Inc. (US) | 2020-06-17 | — | — | EP | disclosed |
| WO-2019032863-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2019-02-14 | — | — | WO | disclosed |