Sugi Predict

Sugi Predict / Compounds / SCHEMBL21685740

SCHEMBL21685740

SCHEMBL21685740

CC(C)(C)OC(=O)N1CCN(c2ccc3c(n2)CCC(NC(=O)OCc2ccccc2)C3)CC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ACHE P22303 3/20 0.47
▸ CA1 P00915 2/20 0.47
▸ CA2 P00918 2/20 0.47
▸ MEN1 O00255 2/20 0.44
▸ KMT2A Q03164 2/20 0.44
▸ CKS1B P61024 2/20 0.43
▸ SKP1 P63208 2/20 0.43
▸ SKP2 Q13309 2/20 0.43
▸ L3MBTL1 Q9Y468 1/20 0.43
▸ BACE1 P56817 1/20 0.43
▸ PRMT5 O14744 2/20 0.43
▸ GPR119 Q8TDV5 2/20 0.42
▸ CTSL P07711 1/20 0.42
▸ CTSB P07858 1/20 0.42
▸ CTSK P43235 1/20 0.42
▸ MAPT P10636 2/20 0.42
▸ MAPK1 P28482 2/20 0.42
▸ NPSR1 Q6W5P4 2/20 0.42
▸ NTSR1 P30989 1/20 0.42
▸ ALDH1A1 P00352 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20722476 1.00 ACHE (0.47) ACHECA1CA2MEN1KMT2A
SCHEMBL20722774 0.90 CA1 (0.49) ACHECA1CA2MEN1KMT2A
SCHEMBL21685672 0.90 CA1 (0.49) ACHECA1CA2MEN1KMT2A
SCHEMBL21684984 0.85 ACHE (0.45) ACHECA1CA2MEN1KMT2A
SCHEMBL20722673 0.85 ACHE (0.45) ACHECA1CA2MEN1KMT2A
SCHEMBL29286147 0.85 BACE1 (0.46) ACHECA1CA2MEN1KMT2A
SCHEMBL30968518 0.85 BACE1 (0.46) ACHECA1CA2MEN1KMT2A
SCHEMBL29286149 0.85 BACE1 (0.46) ACHECA1CA2MEN1KMT2A
SCHEMBL21685571 0.84 ACHE (0.49) ACHECA1CA2MEN1KMT2A
SCHEMBL20722411 0.84 ACHE (0.49) ACHECA1CA2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12162888-B2 Carboxamides as ubiquitin-specific protease inhibitors VALO HEALTH, INC. (US) 2024-12-10 — — US disclosed
CN-112867712-B Carboxamide as ubiquitin-specific protease inhibitor 瓦洛早期发现股份有限公司 2024-07-16 — — CN disclosed
US-11524966-B1 Carboxamides as ubiquitin-specific protease inhibitors VALO HEALTH, INC. (US) 2022-12-13 — — US disclosed
US-20210323975-A1 CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS VALO EARLY DISCOVERY, INC. 2021-10-21 — — US disclosed
EP-3833661-A1 CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS Valo Early Discovery, Inc. (US) 2021-06-16 — — EP disclosed
WO-2020033707-A1 CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS FORMA THERAPEUTICS, INC. (US) 2020-02-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11524966-B1 Carboxamides as ubiquitin-specific protease inhibitors USP28, USP25, USP24 ACHE 1811/4885CA1 1259/4885CA2 2429/4885
US-20210323975-A1 CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS USP28, USP25, USP24 ACHE 1811/4885CA1 1259/4885CA2 2429/4885
US-12162888-B2 Carboxamides as ubiquitin-specific protease inhibitors USP28, USP25, USP24 ACHE 1811/4885CA1 1259/4885CA2 2429/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.