Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 2/20 | 0.47 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21685914 | 0.84 | KMT2A (0.49) | CCKBRSIRT5KMT2ATSHRMEN1 | |
| SCHEMBL20722497 | 0.84 | KMT2A (0.49) | CCKBRSIRT5KMT2ATSHRMEN1 | |
| SCHEMBL20722523 | 0.79 | KMT2A (0.50) | SIRT5KMT2APOLBCYP2D6CYP2C9 | |
| SCHEMBL20722526 | 0.79 | KMT2A (0.50) | SIRT5KMT2APOLBCYP2D6CYP2C9 | |
| SCHEMBL20722524 | 0.79 | KMT2A (0.50) | SIRT5KMT2APOLBCYP2D6CYP2C9 | |
| SCHEMBL28568885 | 0.75 | SIRT5 (0.45) | CCKBRSIRT5SMN1; SMN2KMT2ABRD4 | |
| SCHEMBL20722821 | 0.73 | S1PR5 (0.47) | KMT2APOLB | |
| SCHEMBL6073067 | 0.72 | KDM4E (0.45) | CCKBRSIRT5SMN1; SMN2KMT2APOLB | |
| SCHEMBL23938197 | 0.70 | HPGD (0.38) | SIRT5KMT2ABRD4HPGDTSHR | |
| SCHEMBL21685014 | 0.70 | HPGD (0.38) | SIRT5KMT2ABRD4HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3665169-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | Forma Therapeutics, Inc. (US) | 2020-06-17 | — | — | EP | disclosed |
| WO-2019032863-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2019-02-14 | — | — | WO | disclosed |