Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GCGR | P47871 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20723047 | 0.88 | MAPT (0.42) | MAPTTDP1PIN1KDM4EHSD17B10 | |
| SCHEMBL20723203 | 0.87 | TP53 (0.45) | MAPTTDP1PIN1KDM4EALDH1A1 | |
| SCHEMBL20723261 | 0.81 | TSHR (0.49) | CRHR1MAPTKDM4EHSD17B10LMNA | |
| SCHEMBL20722968 | 0.78 | MAPT (0.49) | CRHR1MAPTTDP1PIN1KDM4E | |
| SCHEMBL20723262 | 0.77 | MAPT (0.39) | MAPTTDP1KDM4EHSD17B10LMNA | |
| SCHEMBL20723241 | 0.77 | CRHR1 (0.43) | CRHR1MAPTTDP1KDM4ESMN1; SMN2 | |
| SCHEMBL20723234 | 0.76 | CRHR1 (0.50) | CRHR1MAPTTDP1KDM4EHSD17B10 | |
| SCHEMBL20723019 | 0.74 | GLA (0.48) | MAPTTDP1KDM4EHSD17B10LMNA | |
| SCHEMBL20722966 | 0.74 | CRHR1 (0.54) | CRHR1MAPTTDP1KDM4EHSD17B10 | |
| SCHEMBL20723160 | 0.72 | MAPT (0.48) | MAPTTDP1KDM4EHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3664806-A1 | APELIN RECEPTOR AGONISTS AND METHODS OF USE THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2020-06-17 | — | — | EP | disclosed |
| WO-2019032720-A1 | APELIN RECEPTOR AGONISTS AND METHODS OF USE THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2019-02-14 | — | — | WO | disclosed |