Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20723047 | 0.90 | MAPT (0.42) | TP53THRBPIN1NPSR1MAPT | |
| SCHEMBL20723218 | 0.87 | CRHR1 (0.49) | TP53THRBPIN1NPSR1MAPT | |
| SCHEMBL20723241 | 0.82 | CRHR1 (0.43) | TP53NPSR1MAPTKDM4ETDP1 | |
| SCHEMBL20723262 | 0.78 | MAPT (0.39) | NPSR1MAPTKDM4ETDP1L3MBTL1 | |
| SCHEMBL20723101 | 0.77 | TP53 (0.44) | TP53THRBPIN1MDM2NPSR1 | |
| SCHEMBL20723261 | 0.77 | TSHR (0.49) | TP53NPSR1MAPTKDM4EL3MBTL1 | |
| SCHEMBL20723019 | 0.75 | GLA (0.48) | TP53THRBNPSR1MAPTKDM4E | |
| SCHEMBL20723196 | 0.74 | GABRA2 (0.49) | TP53THRBNPSR1MAPTKDM4E | |
| SCHEMBL20723240 | 0.74 | GCGR (0.37) | NPSR1MAPTKDM4ETDP1L3MBTL1 | |
| SCHEMBL20723099 | 0.73 | TP53 (0.47) | TP53THRBNPSR1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3664806-A1 | APELIN RECEPTOR AGONISTS AND METHODS OF USE THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2020-06-17 | — | — | EP | disclosed |
| WO-2019032720-A1 | APELIN RECEPTOR AGONISTS AND METHODS OF USE THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2019-02-14 | — | — | WO | disclosed |