Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | GNRHR | P30968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20723241 | 0.88 | CRHR1 (0.43) | MAPTKDM4ENPSR1TDP1L3MBTL1 | |
| SCHEMBL20723261 | 0.86 | TSHR (0.49) | MAPTKDM4ENPSR1L3MBTL1ALDH1A1 | |
| SCHEMBL20723047 | 0.80 | MAPT (0.42) | MAPTKDM4ENPSR1TDP1L3MBTL1 | |
| SCHEMBL20723203 | 0.78 | TP53 (0.45) | MAPTKDM4ENPSR1TDP1L3MBTL1 | |
| SCHEMBL20723218 | 0.77 | CRHR1 (0.49) | MAPTGCGRKDM4ENPSR1TDP1 | |
| SCHEMBL20723004 | 0.75 | CFTR (0.39) | MAPTKDM4ENPSR1ALDH1A1HPGD | |
| SCHEMBL20723240 | 0.73 | GCGR (0.37) | MAPTGCGRKDM4ENPSR1TDP1 | |
| SCHEMBL20723091 | 0.73 | NPSR1 (0.46) | MAPTKDM4ENPSR1TDP1L3MBTL1 | |
| SCHEMBL20723019 | 0.72 | GLA (0.48) | MAPTATMKDM4ENPSR1TDP1 | |
| SCHEMBL24455330 | 0.70 | MAPT (0.38) | MAPTKDM4ENPSR1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3664806-A1 | APELIN RECEPTOR AGONISTS AND METHODS OF USE THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2020-06-17 | — | — | EP | disclosed |
| WO-2019032720-A1 | APELIN RECEPTOR AGONISTS AND METHODS OF USE THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2019-02-14 | — | — | WO | disclosed |