Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19825999 | 0.87 | SMN1; SMN2 (0.46) | ALDH1A1NPC1HTTRAB9AMAPT | |
| SCHEMBL8544515 | 0.79 | RXFP1 (0.62) | ALDH1A1NPC1HTTRAB9AMAPT | |
| SCHEMBL10057892 | 0.78 | TDP1 (0.60) | ALDH1A1NPC1HTTRAB9AMAPT | |
| SCHEMBL12209638 | 0.78 | MAPT (0.60) | ALDH1A1NPC1HTTRAB9AMAPT | |
| SCHEMBL8297116 | 0.77 | ALDH1A1 (0.48) | ALDH1A1NPC1HTTRAB9AMAPT | |
| SCHEMBL12190501 | 0.77 | KIF11 (0.52) | ALDH1A1NPC1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL14768879 | 0.77 | ALDH1A1 (0.59) | ALDH1A1NPC1HTTRAB9AMAPT | |
| SCHEMBL13460760 | 0.76 | IDO1 (0.47) | ALDH1A1HTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL13424786 | 0.76 | MEN1 (0.52) | ALDH1A1NPC1HTTRAB9AMAPT | |
| SCHEMBL22384713 | 0.76 | NPC1 (0.43) | ALDH1A1NPC1HTTRAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2707101-B1 | PROTEOSTASIS REGULATORS | PROTEOSTASIS THERAPEUTICS INC (US) | 2019-02-13 | — | — | EP | disclosed |