Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.37 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9400807 | 0.73 | SPHK1 (0.38) | SPHK2SPHK1CETP | |
| SCHEMBL7775347 | 0.73 | ALDH1A1 (0.37) | — | |
| SCHEMBL1040028 | 0.72 | — | — | |
| SCHEMBL2975409 | 0.71 | — | — | |
| SCHEMBL17888811 | 0.69 | TDP1 (0.35) | — | |
| SCHEMBL19092286 | 0.68 | SPHK2 (0.33) | SPHK2SPHK1CETP | |
| SCHEMBL18938554 | 0.67 | DNM1 (0.48) | SPHK1 | |
| SCHEMBL21021570 | 0.67 | ALDH1A1 (0.33) | SPHK2SPHK1CETP | |
| SCHEMBL18849897 | 0.67 | DNM1 (0.32) | — | |
| SCHEMBL18938552 | 0.67 | DNM1 (0.48) | SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3782655-A1 | A METHOD FOR THE TREATMENT OF POMPE DISEASE USING 1-DEOXYNOJIRIMYCIN AND DERIVATIVES | Amicus Therapeutics, Inc. (US) | 2021-02-24 | — | — | EP | disclosed |
| EP-3441090-A1 | A METHOD FOR THE TREATMENT OF POMPE DISEASE USING 1-DEOXYNOJIRIMYCIN AND DERIVATIVES | Amicus Therapeutics, Inc. (US) | 2019-02-13 | — | — | EP | disclosed |