Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.33 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8252490 | 0.71 | LMNA (0.39) | SPHK1CETP | |
| SCHEMBL19132625 | 0.70 | CYP2D6 (0.32) | SPHK1CETP | |
| SCHEMBL7778192 | 0.70 | CA12 (0.33) | — | |
| SCHEMBL30353887 | 0.69 | TDP1 (0.35) | — | |
| SCHEMBL2058302 | 0.69 | SPHK1 (0.37) | SPHK1CETP | |
| SCHEMBL2454531 | 0.69 | ALDH1A1 (0.36) | SPHK1CETP | |
| SCHEMBL331155 | 0.68 | MMP1 (0.38) | SPHK1 | |
| SCHEMBL3386408 | 0.68 | SPHK1 (0.36) | SPHK2SPHK1CETP | |
| SCHEMBL20726267 | 0.68 | SPHK2 (0.37) | SPHK2SPHK1CETP | |
| SCHEMBL2058526 | 0.67 | MMP1 (0.34) | SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3957320-B1 | AUGMENTED ACID ALPHA-GLUCOSIDASE FOR THE TREATMENT OF POMPE DISEASE | AMICUS THERAPEUTICS INC (US) | 2023-08-23 | — | — | EP | disclosed |
| EP-3957320-A1 | AUGMENTED ACID ALPHA-GLUCOSIDASE FOR THE TREATMENT OF POMPE DISEASE | Amicus Therapeutics, Inc. (US) | 2022-02-23 | — | — | EP | disclosed |
| EP-3397273-B1 | AUGMENTED ACID ALPHA-GLUCOSIDASE FOR THE TREATMENT OF POMPE DISEASE | AMICUS THERAPEUTICS INC (US) | 2021-05-19 | — | — | EP | disclosed |
| WO-2017173059-A1 | METHOD FOR SELECTION OF HIGH M6P RECOMBINANT PROTEINS | AMICUS THERAPEUTICS, INC. (US) | 2017-10-05 | — | — | WO | disclosed |
| WO-2017117407-A1 | AUGMENTED ACID ALPHA-GLUCOSIDASE FOR THE TREATMENT OF POMPE DISEASE | AMICUS THERAPEUTICS, INC. (US) | 2017-07-06 | — | — | WO | disclosed |