Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 4/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 3/20 | 0.35 |
| ▸ | USP8 | P40818 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 4/20 | 0.35 |
| ▸ | PHGDH | O43175 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20726500 | 1.00 | CDK1 (0.36) | CDK1CDK2LOXL2SYKCFTR | |
| SCHEMBL20726458 | 0.90 | PRKAG1 (0.40) | SYKPRKAG1PRKAA1PRKAB1RORC | |
| SCHEMBL20726502 | 0.85 | BRD4 (0.39) | USP8 | |
| SCHEMBL20726357 | 0.84 | BRD4 (0.40) | USP8 | |
| SCHEMBL20726517 | 0.83 | PRKAG1 (0.39) | CFTRPRKAG1PRKAA1PRKAB1USP8 | |
| SCHEMBL20726412 | 0.83 | PRKDC (0.43) | CFTRPRKAG1PRKAA1PRKAB1USP8 | |
| SCHEMBL20726513 | 0.81 | EGFR (0.33) | — | |
| SCHEMBL20726495 | 0.81 | EGFR (0.35) | — | |
| SCHEMBL20726527 | 0.78 | USP2 (0.41) | PRKAG1PRKAA1PRKAB1 | |
| SCHEMBL20726351 | 0.76 | BRD4 (0.41) | USP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083611-B1 | OXINDOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE IN THE TREATMENT OF AMPK-RELATED DISEASES | SANOFI SA (FR) | 2019-02-13 | — | — | EP | disclosed |