Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | TGM2 | P21980 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20726502 | 0.86 | BRD4 (0.39) | EGFRCHEK1KDRBRD4 | |
| SCHEMBL20726357 | 0.85 | BRD4 (0.40) | EGFRCHEK1BRD4 | |
| SCHEMBL20726412 | 0.84 | PRKDC (0.43) | CHEK1BRD4 | |
| SCHEMBL20726513 | 0.81 | EGFR (0.33) | EGFR | |
| SCHEMBL20726500 | 0.81 | CDK1 (0.36) | — | |
| SCHEMBL20726432 | 0.81 | CDK1 (0.36) | — | |
| SCHEMBL20726351 | 0.77 | BRD4 (0.41) | EGFRCHEK1BRD4 | |
| SCHEMBL20726381 | 0.76 | PGR (0.43) | EGFRKDRPDPK1BRD4 | |
| SCHEMBL20726382 | 0.75 | EGFR (0.48) | EGFRCHEK1KDR | |
| SCHEMBL20726352 | 0.74 | PRKAG1 (0.40) | CHEK1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083611-B1 | OXINDOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE IN THE TREATMENT OF AMPK-RELATED DISEASES | SANOFI SA (FR) | 2019-02-13 | — | — | EP | disclosed |