Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 7/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | GLB1 | P16278 | 1/20 | 0.36 |
| ▸ | CTRC | Q99895 | 1/20 | 0.36 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20726393 | 0.87 | EGFR (0.39) | EGFRBRD4KDRBRD2PDPK1 | |
| SCHEMBL20726459 | 0.85 | BRD4 (0.38) | EGFRBRD4KDRBRD2 | |
| SCHEMBL20726384 | 0.81 | PDE3B (0.50) | EGFRBRD4KDR | |
| SCHEMBL23612447 | 0.80 | HPGD (0.47) | EGFRBRD4LMNAERBB2IGF1R | |
| SCHEMBL20726416 | 0.79 | ALOX5 (0.41) | EGFRBRD4KDRMCL1 | |
| SCHEMBL20726374 | 0.79 | PRKAB2 (0.45) | EGFRGPR35BRD4MEN1USP2 | |
| SCHEMBL20726370 | 0.76 | ACMSD (0.42) | EGFRBRD4KDRBRD2 | |
| SCHEMBL20726351 | 0.76 | BRD4 (0.41) | EGFRBRD4MEN1MAPTKMT2A | |
| SCHEMBL20726366 | 0.75 | NEK1 (0.42) | EGFRBRD4 | |
| SCHEMBL20726436 | 0.75 | EGFR (0.39) | EGFRBRD4KDRBRD2PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083611-B1 | OXINDOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE IN THE TREATMENT OF AMPK-RELATED DISEASES | SANOFI SA (FR) | 2019-02-13 | — | — | EP | disclosed |